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Combining 4D MRI and 4DCT for Personalized Volumetric Motion Monitoring in Lung Radiation Therapy

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The purpose of this study is to assess a real time motion tracking of lung tumors and important organs next to the tumor while breathing during a participant's radiation treatment. This will be assessed through a four-dimensional magnetic resonance imaging (MRI) scan before starting your radiation treatment and x-ray fluoroscopy images that are taken during radiation

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Adult (≥18 years) patients (both sexes) with histologically diagnosed Stage II-IIIb NSCLC

• Patients to be treated with definitive external beam photon radiotherapy with or without systemic therapy (e.g., chemotherapy, immunotherapy).

• No restrictions on number radiotherapy fractions, or location/number of lesions

• ECOG performance status ≤ 3

• Ability to undergo MRI scans

• Patient has signed informed consent document and agreed to study procedures

Locations
United States
Maryland
University of Maryland Greenebaum Cancer Center
RECRUITING
Baltimore
Contact Information
Primary
Amit Sawant, PhD
asawant@som.umaryland.edu
410-328-6080
Backup
Caitlin Eggleston, MPH
caitlineggleston@umm.edu
410-369-5351
Time Frame
Start Date: 2026-04-14
Estimated Completion Date: 2029-04
Participants
Target number of participants: 44
Treatments
Experimental: Imaging
At baseline, patients will receive a 4D CT Simulation (standard of care) along with a 4D MRI with surface monitoring (research).~During their radiation treatment, they will receive additional fluoroscopy imaging and surface monitoring.
Related Therapeutic Areas
Sponsors
Leads: University of Maryland, Baltimore

This content was sourced from clinicaltrials.gov