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The Effects of Low-Intensity Endurance Exercise on Improving Fatigue, Sleep, Quality of Life, Mitochondrial Function, Cellular Bioelectrical Impedance Phase Angle, and Predictors of Exercise Adherence in Patients With Lung Cancer

Status: Recruiting

Location: See location...

Intervention Type: Behavioral

Study Type: Interventional

Study Phase: Not Applicable

SUMMARY

To conduct a randomized controlled trial (RCT) targeting lung cancer patients with cancer-related fatigue to achieve the following objectives: Objective 1: To investigate whether a low-intensity endurance exercise intervention can effectively improve mitochondrial DNA content, mitochondrial function, mitochondrial oxidative phosphorylation complex enzyme concentrations, cellular bioelectrical impedance phase angle, cancer-related fatigue, and quality of life in lung cancer patients with cancer-related fatigue. Objective 2: To explore whether the low-intensity endurance exercise intervention improves cancer-related fatigue and quality of life in lung cancer patients through direct or indirect effects by modulating mitochondrial DNA content, mitochondrial function, mitochondrial oxidative phosphorylation complex enzyme concentrations, and cellular bioelectrical impedance phase angle. Objective 3: To investigate the correlation between personality traits and adherence to low-intensity endurance exercise in lung cancer patients. Objective 4: To investigate whether a low-intensity endurance exercise intervention can effectively improve sleep quality in lung cancer patients with cancer-related fatigue. Objective 5: To investigate whether a low-intensity endurance exercise intervention can effectively reduce stress in lung cancer patients with cancer-related fatigue.

Eligibility

Participation Requirements

Sex: All

Minimum Age: 20

Healthy Volunteers: f

View:

• Individuals diagnosed with lung cancer by a physician.

• Aged 20 years or older.

• Education level of elementary school graduation or above.

Locations

Other Locations

Taiwan

Taipei Medical University

RECRUITING

Taipei

Contact Information

Primary

Hsiu Ting Tsai, PhD

hsiuting@tmu.edu.tw

886227361661

Backup

Hsin Hui Huang, Master's degree

d432113014@tmu.edu.tw

886227361661

Time Frame

Start Date: 2026-07-01

Estimated Completion Date: 2029-07

Participants

Target number of participants: 450

Treatments

No_intervention: Control Group

Participants assigned to the control group will not receive any exercise intervention and will be instructed to maintain their usual daily lifestyle and physical activity throughout the study period.

Experimental: continuous exercise group

Participants will perform Level 2 low-intensity continuous endurance exercise for at least 30 consecutive minutes per day, 5 days per week. Exercise intensity will be maintained at 75-80% of peak heart rate (HRpeak), corresponding to a Rating of Perceived Exertion (RPE) of 11-12 (light). Each exercise session will consist of a 5-minute warm-up, 30 minutes of continuous low-intensity endurance exercise, and a 10-minute cool-down.

Experimental: low-intensity exercise group

Participants will perform 30 minutes of interval endurance exercise per day, 5 days per week. Each session will consist of five alternating cycles, with each cycle including 3 minutes of Level 2 low-intensity endurance exercise at 75-80% HRpeak (RPE 11-12), followed by 3 minutes of Level 1 very low-intensity endurance exercise at 65-75% HRpeak (RPE \<11). Each exercise session will begin with a 5-minute warm-up and conclude with a 10-minute cool-down.

Related Therapeutic Areas

Lung Cancer

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