Lymphedema Clinical Trials

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ULTRASONOGRAPHIC EVALUATION OF LOWER EXTREMITY SKIN AND SUBCUTANEOUS TISSUE WITH QUANTITATIVE ECHOGENICITY AND ELASTOGRAPHY IN LYMPHEDEMA, LIPEDEMA, AND HEALTHY CONTROL GROUPS: A CONTROLLED CLINICAL STUDY

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

The aim of this observational study is to evaluate the diagnostic value of multimodal ultrasonography in differentiating between lymphedema and lipedema. Differentiating these two chronic conditions based solely on clinical examination can be challenging due to overlapping symptoms. This study will utilize various non-invasive ultrasound techniques-including B-mode ultrasound, strain elastography, power Doppler, and quantitative ImageJ analysis-to compare tissue characteristics among patients with lymphedema, patients with lipedema, and healthy controls. The goal is to identify reliable, non-invasive imaging biomarkers that can facilitate early and accurate diagnosis, thereby optimizing patient management.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: t
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• Individuals aged 18 to 75 years.

• Clinical diagnosis of lower extremity lymphedema (for the lymphedema group).

• Clinical diagnosis of lower extremity lipedema (for the lipedema group).

• Healthy individuals with no history or clinical signs of chronic lower extremity edema (for the control group).

Locations
Other Locations
Turkey
Kayseri City Hospital
RECRUITING
Kayseri
Contact Information
Primary
Abdullah Goktug Yazar
abdullahgoktug.yazar@sbu.edu.tr
+905309731140
Time Frame
Start Date: 2026-03-19
Estimated Completion Date: 2026-09-15
Participants
Target number of participants: 75
Treatments
Lymphedema Group
Patients clinically diagnosed with lower extremity lymphedema. Participants in this group will undergo a non-invasive multimodal ultrasound assessment (including B-mode, strain elastography, power Doppler, and ImageJ analysis) to evaluate tissue characteristics.
Lipedema Group
Patients clinically diagnosed with lipedema of the lower extremities. Participants in this group will undergo the identical non-invasive multimodal ultrasound assessment protocol to evaluate tissue echogenicity, thickness, and stiffness.
Healthy Control Group
Healthy volunteers with no history or clinical signs of chronic lower extremity edema, lymphedema, or lipedema. This group will undergo the same multimodal ultrasound assessment to establish baseline normative values for comparison.
Related Therapeutic Areas
Sponsors
Leads: Kayseri City Hospital

This content was sourced from clinicaltrials.gov