Lymphedema Clinical Trials

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The Effect of Resistance Exercise in Patients With Lower Limb Lymphedema - With and With-out Compression - a Randomized Controlled Trial (the LymphEx Study)

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The aim of the study is to investigate the short-term (within 2 weeks) effects of resistance exercise with and without compression garments on lower limb lymphedema(LLL). Additionally, the study will explore the immediate response in LLL to resistance exercise (2 hours and 24 hours post-exercise). Participants will continously wear a circumfencential sensor at the calf (CIMON from Icompression) under a compression garment and an activity tracker (SENS Motion from SENS Innovation Aps) at the thigh for 3 periods (two with supervised exercise sessions of 2 weeks and one control period). Participants will attend supervised resistance exercise 2-3 times per week for 2 periods of 2 weeks (one with compression garment and one without). Assessments with the principal investigator will be scheduled before and after every 2 week period. Participants will keep a digital diary or diary in paper of their lymphedema related symptoms and experienced issues with the sensors or app.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• verified diagnosis of lymphedema of the lower limb

• completed compression bandaging

• adherence to compression garment in daytime (minumum 5-6 days per week)

• calf circumference \> 35 and \<75 cm

Locations
Other Locations
Denmark
Herlev and Gentofte Hospital, Department of Physiotherapy and Occupational Therapy
RECRUITING
Herlev
Contact Information
Primary
Merete C Wittenkamp, PhD student
merete.celano.wittenkamp@regionh.dk
93911784
Time Frame
Start Date: 2026-04
Estimated Completion Date: 2027-03
Participants
Target number of participants: 36
Treatments
Experimental: Group A
Week 1-2 no exercise, week 3 washout, week 4-5 exercise without compression, week 6 washout, week 7-8 exercise with compression
Experimental: Group B
Week 1-2 exercise without compression, week 3 washout, week 4-5 exercise with compression, week 6 washout, week 7-8 no exercise
Experimental: Group C
Week 1-2 exercise with compression, week 3 washout, weekend 4-5 no exercise, week 6 washout, week 7-8 exercise without compression
Related Therapeutic Areas
Sponsors
Leads: Carsten Bogh Juhl

This content was sourced from clinicaltrials.gov