MRI Markers of Feedback Timing During Learning in Individuals with TBI with and Without Clinical Depression
Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The goal of this proposal is to examine the influence of feedback timing on learning and brain function in individuals with moderate-to-severe traumatic brain injury (TBI), with and without depression.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: t
View:
• I am between the ages of 18 and 65.
• I have been diagnosed with a TBI.
• I am an individual without TBI.
• I am right-handed.
• I have normal vision or corrected to normal vision.
• I can read and speak English fluently.
• I do or do not have a current diagnosis of Depression.
• I am not currently pregnant.
Locations
United States
New Jersey
Kessler Foundation
RECRUITING
West Orange
Contact Information
Primary
Julia McMillan, BA
jmcmillan@kesslerfoundation.org
973-323-3684
Backup
Belinda Washington, BA
bwashington@kesslerfoundation.org
973-324-8446
Time Frame
Start Date: 2021-09-01
Estimated Completion Date: 2026-01-31
Participants
Target number of participants: 180
Treatments
Experimental: Traumatic Brain Injury (TBI)
Individuals with moderate-to-severe injury severity, defined as post-traumatic amnesia lasting more than 24hrs, loss of consciousness lasting more than 30 min, Glasgow Coma Scale (GCS) score less than 13.
Experimental: Traumatic Brain Injury (TBI) with MDD
Individuals with moderate-to-severe injury severity, defined as post-traumatic amnesia lasting more than 24hrs, loss of consciousness lasting more than 30 min, Glasgow Coma Scale (GCS) score less than 13. In addition, individuals will have a diagnosis of major depressive disorder (MDD) as per DSM-5.
Experimental: Major Depressive Disorder (MDD)
Individuals meeting criteria for major depressive disorder (MDD) including qualifiers 'in partial remission' or 'in full remission' if they are actively in treatment for the condition and still carry the depression diagnosis.
Experimental: Healthy Individuals
Healthy individuals without psychiatric and neurological conditions.
Authors
Ekaterina Dobryakova
Related Therapeutic Areas
Sponsors
Leads: Kessler Foundation
Collaborators: National Institute of Neurological Disorders and Stroke (NINDS), Moss Rehabilitation Research Institute