⁃ Rollover participants are eligible for the study if the following inclusion criteria are met:

• Completed a previous NMRA-335140 Phase 3 MDD study (example: NMRA-335140-301, NMRA-335140-302, or NMRA-335140-303) according to the completion definition in the parent study protocol.

• Signed an informed consent form (ICF) for this study.

• Willing to comply with the contraception requirements described in the inclusion criteria of the parent study protocol.

• Willing to comply with the concomitant medication/therapy restrictions described in the exclusion criteria of the parent study protocol.