Effect of Transcranial Alternating Current Stimulation (tACS) on Serotonin-1A Receptor in Patients With Major Depressive Disorder
Status: Recruiting
Location: See location...
Intervention Type: Other, Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study will apply a comprehensive tools that integrates neuroimaging, psychological evaluation, and sleep monitoring through 18F-MPPF PET/MR, neuropsychological tests, and polysomnography (PSG) to explore the neurobiological mechanisms underlying transcranial alternating current stimulation (tACS) for depressive disorders, mainly focusing on the serotonergic system revealed by Serotonin-1A (5-HT1A) receptor.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: t
View:
• To undergo PET/MR examinations.
• Be matched with the patient group regarding age, sex, and educational level.
Locations
Other Locations
China
Xuanwu Hospital
RECRUITING
Beijing
Contact Information
Primary
Wenfeng Zhao, MD
fengfeng_zw@ccmu.edu.cn
+8613051118863
Backup
Hongxing Wang, MD & PhD
wanghongxing@xwh.ccmu.edu.cn
+861083198650
Time Frame
Start Date: 2024-01-31
Estimated Completion Date: 2025-05-31
Participants
Target number of participants: 40
Treatments
Experimental: Depressive disorders
Three conductive electrodes will be placed overhead. Based on the 10/20 international placement system, a 4.45 x 9.53 cm electrode is placed on the forehead corresponding to Fpz, Fp1 and Fp2. Two 3.18 x 3.81 cm electrodes are placed on the mastoid region of each side.~The tACS stimulation waveform includes ramp-up and ramp-down periods of 180 and 12 s, respectively. It is a square-wave with an average amplitude of 15 mA and is equally distributed from the frontal region to the mastoid areas (amplitudes are reported as zero-to-peak).~All participants with major depression disorder will receive a total of 20 sessions in four weeks, once daily on weekdays, with tACS stimulation at 77.5 Hz and 15 mA.~From Monday to Friday, each session will last 40 min at a fixed daytime interval.
Other: Healthy controls
Without the tACS stimulation in this group
Related Therapeutic Areas
Sponsors
Leads: Xuanwu Hospital, Beijing