Repetitive Transcranial Magnetic Stimulation(rTMS) Treatment Based on Personalized Modulation of Electroencephalography Promotes Symptom Remission in Major Depressive Disorder (MDD) - A Randomized Controlled Clinical Trial

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study will focus on the hypothesis that repetitive transcranial magnetic stimulation (TMS) based on EEG personalized modulation may be more effective in promoting symptomatic relief of major depressive disorder (MDD), and will rely on the platform of neuroimaging and function brain imaging of Shanghai Mental Health Center (SMHC), an authoritative institution in the field of mental health. We will eventually facilitate optimization of physical therapy for major depressive disorder (MDD).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 16
Maximum Age: 65
Healthy Volunteers: f
View:

• The diagnosis of participants should be made in accordance to the diagnostic criteria described for Major Depressive Disorder (MDD) of the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-V).

• be willing to receive neuromodulation therapy and sign the written informed consent

• an age of 16-65 years

• The patient's medication regimen is based on only one antidepressant, and the medication regimen is not adjusted as much as possible during the treatment period.

• Having a total score of not less than 20 on the Hamilton Depression Rating Scale (HAMD-24).

• sufficient hearing or reading ability

Locations
Other Locations
China
Shanghai Mental Health Center
RECRUITING
Shanghai
Contact Information
Primary
TianHong Zhang, Doctor
zhang_tianhong@126.com
13127577024
Time Frame
Start Date: 2024-05-27
Estimated Completion Date: 2026-05
Participants
Target number of participants: 70
Treatments
Experimental: The Precision Group
Patients in the precision group will be treated with Individualized alpha frequency Transcranial Magnetic Stimulation (αTMS) Treatment.
Active_comparator: The Conventional Group
Patients in the conventional group will be treated with 10Hz-frequency TMS over the left dorsolateral prefrontal cortex (DLPFC).
Related Therapeutic Areas
Sponsors
Leads: Shanghai Mental Health Center
Collaborators: National Natural Science Foundation of China, Shanghai Jiao Tong University School of Medicine, Shanghai Municipal Science and Technology Commission

This content was sourced from clinicaltrials.gov