Social Cognition, Memory, and Executive Functions in Bipolar Disorder and Major Depressive Disorder

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Bipolar disorder (BD) are common psychiatric disorders often misdiagnosed, leading to delayed treatment. Even during stable phases, individuals with bipolar disorder experience residual cognitive impairments that affect their social functioning and quality of life. This study aims to explore social cognition deficits (e.g., emotional processing, theory of mind, attribution bias) and their relationship with executive functions (e.g., flexibility, inhibition, working memory) and memory in bipolar disorder and major depressive disorder, ultimately seeking to improve understanding of their functional outcomes. Social cognition and executive functions in BD are both state- and trait-related. One recent meta-analysis demonstrated impairment in social cognitive domains for manic, depressive, and euthymic bipolar disorders' patients but it remains unclear whether these social cognitive deficits in BD are due to executive functions and/or other confounding effects. Few studies have investigated the interdependency between these cognitive impairments in these two affective disorders while a better understanding of the link between executive functions and social cognition seems crucial in order to better characterize the nature of patients' deficits and thus their caring.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: t
View:

• Patients between 18 and 65 years old, men or women

• Having a diagnosis of bipolar disorder or depressive disorder

• No substantial change in treatment for 2 weeks preceding study enrollment

• Being a native French speaker

• Patients enrolled in the national healthcare insurance program

• Consenting to participate to the study

• Participants between 18 and 65 years old, men or women

• Participants having at least one first-degree relative presenting an bipolar disorder (parents, children, siblings)

• Being a native French speaker

• Patients enrolled in the national healthcare insurance program

• Consenting to participate to the study

• Participants between 18 and 65 years old, men or women

• Being a native French speaker

• Patients enrolled in the national healthcare insurance program

• Consenting to participate to the study

Locations
Other Locations
France
Chu Reims
RECRUITING
Reims
Contact Information
Primary
Arthur KALADJIAN
kaladjiana@epsm-marne.fr
03 26 78 70 45
Backup
Sarah BARRIERE
barrieres@epsm-marne.fr
03 26 78 70 45
Time Frame
Start Date: 2025-01-07
Estimated Completion Date: 2028-02-07
Participants
Target number of participants: 180
Treatments
Experimental: Bipolar patients
Patients with a diagnosis of bipolar disorder
Experimental: Major depressive patients
Patients with a diagnosis of major depressive disorder
Experimental: First-degree relatives of bipolar patients
First-degree relatives of bipolar patients
Experimental: Bipolar controls
Healthy control participants matched to group 1
Experimental: Depressive controls
Healthy control participants matched to group 2
Experimental: First-degree controls
Healthy control participants matched to group 3
Sponsors
Leads: CHU de Reims

This content was sourced from clinicaltrials.gov