Major Depression Clinical Trials

• Participant has a primary diagnosis of recurrent MDD (moderate or severe) or persistent depressive disorder.

• Participant has had an inadequate response to oral antidepressant treatments in the current episode of depression.

• Participant must have been taking oral antidepressants for at least 8 weeks and is willing to continue the same oral antidepressants at the same dose and frequency of administration throughout participation in the study.

• Total Hamilton Depression Rating Scale-17 Item (HAM-D17) score ≥22 at screening and at study baseline (Day 1).

• Willing and able to comply with all study procedures and restrictions in the opinion of the investigator.