Examining the Effects of Escitalopram and Memantine on Pattern Separation in Major Depressive Disorder
This study seeks to examine the effects of treatment with a selective serotonin reuptake inhibitor (SSRI), escitalopram, a first-line treatment for depression, in combination with placebo or with extended-release memantine, on neuropsychological function, regional brain activity assessed by functional magnetic resonance imaging, and depressive symptoms, in participants with Major Depressive Disorder. Escitalopram is administered in an open-label fashion in this study; extended release memantine is administered in a double-blind, randomized, placebo-controlled manner.
• Age 18-50
• Current diagnosis of MDD without psychotic features assessed within three weeks of study enrollment
• 17-item Hamilton Depression Rating Scale score ≥17 assessed within 3 weeks of study enrollment
• Using an effective form of contraception at study enrollment and agrees to continue throughout study participation for individuals of child-bearing potential
• Capacity to provide informed consent
• Proficient in English
• Willing to provide emergency contact