Neurobiological and Genomic Predictors of Relapse After Discontinuation of Antidepressant Treatment in Major Depressive Disorder: An Observational Prospective Study
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Observational
SUMMARY
The goal of this observational study is to test whether the discontinuation of antidepressant medications for patients with depression can be decided after the normalization of biological parameters. The main questions it aims are: 1. When patients with depression treated with antidepressants, does their brain activity also become normal? If so, 2. Then, can we stop the antidepressant treatment and expect minimum repeat of depression? The participants who receive a specific antidepressant treatment will be asked to: * Undergo quantitative electroencephalography (qEEG), * Record Event-related potential (ERP), * Record Sleep EEG * Answer Hamilton Depression Rating Scale question their psychiatrists asked * Give blood sample for genetic analysis * Repeat the above mentioned procedures for at least 3 times during their treatment period. Researchers will compare the results of patients with the results of healthy controls.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: t
View:
• Outpatients
• For patients, satisfying Major Depressive Disorder for Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR)
• Drug-free for at least 1-week
Locations
Other Locations
Turkey
Prof. Dr. Kemal Arıkan's Psychiatry Clinic
RECRUITING
Istanbul
Contact Information
Primary
Mehmet Kemal Arıkan, Prof.
mkarikan46@gmail.com
+905325555005
Backup
Reyhan Ilhan, MSc.
psy.reyhan.ilhan@gmail.com
05378586677
Time Frame
Start Date:2025-01-01
Estimated Completion Date:2027-02-01
Participants
Target number of participants:204
Treatments
Depression-Relapsed Prospectively Followed
This cohort includes patients whose long-term outcome is unknown at the start of the study. They are enrolled, treated, and monitored over time. At the study's conclusion, they will be retrospectively categorized as Relapsers.
Healthy Control
This group is composed of individuals with no history of psychiatric illness. Data is collected at a single time point to establish a healthy baseline for all biomarkers.
Recurrent Depression Retrospectively Defined
Group A (Retrospective / Known Phenotype): This group consists of patients with a confirmed history of recurrent depression. Recurrence defined as no relapse within 1 year after discontinuation of medication. Data for this group is collected at a single time point (Baseline/T0).
Non-Recurrent Depression Retrospectively Defined
This group consists of patients with a confirmed history of a single depressive episode or no relapse within 1 year after discontinuation of medication. Data for this group is collected at a single time point (Baseline/T0).
Depression-Non-Relapsers Prospectively Followed
This cohort includes patients whose long-term outcome is unknown at the start of the study. They are enrolled, treated, and monitored over time. At the study's conclusion, they will be retrospectively Non-Relapsers (in Remission).