‣ Patients will be enrolled in the study if they meet all the following criteria:

• Patients must understand and provide written informed consent before they can participate in the study. They must understand the study procedures and be willing to complete the required assessments;

• Male and female patients aged ≥ 18 years;

• SBS patients with intestinal failure and without colon-in-continuity who are not eligible or not willing to receive an approved marketed GLP-2;

• Patients with history of SBS resulting in intestinal failure caused by a major intestinal resection (e.g., injury, cancer\*, Crohn's disease, vascular disease, volvulus) without colon-in-continuity (patients with duodenostomy, Jejunostomy or Ileostomy). Intestinal failure will be defined according to the recommendations of the European Society for Clinical Nutrition and Metabolism (ESPEN), i.e., a reduction of gut function below the minimum necessary for the absorption of macronutrients and/or water and electrolytes, such that intravenous (IV) supplementation is required to maintain health and/or growth. \*Patients with history of cancer, should be in remission for the last 6 months and with not ongoing anticancer therapy (long-term hormonal therapy is allowed).

• Minimum remaining length of 100 cm of small bowel;

• At least 6 months elapsed since last surgical bowel resection;

• No restorative surgery planned during the entire study period;

• Patients with at least 4 continuous months of PS dependency (parenteral nutrition and/or intravenous fluids);

• Chronic non-infectious diarrhoea defined as passage of at least 1 loose watery stool per day for more than 4 consecutive weeks.

⁃ Patients receiving stable parenteral support (fluids, electrolytes and/or nutrients) at least three days per week and a minimum of 2 liters of PS per week, to meet caloric, fluid or electrolytes needs;

⁃ Patients with Crohn's disease will have to be in clinical remission for ≥ 12 weeks;

⁃ Patients must be able to ingest solid or semi-solid foods and drink fluids;

⁃ If taken at screening, use of antimotility and antidiarrheal agents (loperamide, diphenoxylate, codeine and other opiates), H2-receptor antagonists, proton pump inhibitors, bile sequestering agents, oral glutamine, diuretics and oral rehydration solutions is required to be at stable average weekly doses for at least 4 weeks prior to screening evaluations;

⁃ If female and of child-bearing potential, the patient must use an acceptable effective contraceptive measure for the entire study duration and for 4 weeks after the last dose. Acceptable birth control methods that result in a failure rate of more than 1% per year include: progestogen-only oral hormonal contraception, where inhibition of ovulation is not the primary mode of action male or female condom with or without spermicide cap, diaphragm or sponge with spermicide (A combination of male condom with either cap, diaphragm or sponge with spermicide (double barrier methods) are also considered acceptable). Male patients must agree to use an acceptable form of birth control and to not donate sperm during the study and for 4 weeks after the last dose.

⁃ If female and child-bearing potential, the patient must have a negative urine pregnancy test prior the first administration of the investigational product;

⁃ Satisfactory general health status as determined by the investigator based on current medical status, medical history and physical examination.