Loss of Autonomy in the Elderly: Relationships Between Gut Microbiota Diversity, Nutrition and Cognitive and Sensory-motor Disturbances in Small Eaters and Non Small Eaters

Status: Recruiting
Location: See location...
Intervention Type: Other, Biological
Study Type: Observational
SUMMARY

Older adults currently make up 25% of the population in France, and future health expenditures will be largely related to the consequences of aging. Normal aging is associated with a progressive decrease in cognitive and sensorimotor function, malnutrition and/or under-nutrition and intestinal dysbiosis (i.e. changes in the composition and/or stability of the microbiota). Furthermore, admission to long-term care facilities such as Etablissement d'Hébergement pour Personnes Agées Dépendantes (EHPAD) leads to drastic changes in lifestyle in terms of (i) nutrition and (ii) motor functions. These modifications can influence the composition of the intestinal microbiota and its temporal evolution. We will study the relationship between the deterioration of cognitive and sensorimotor function, diet and intestinal well-being (i.e. microbiota) of a cohort of older adults (\>75 years) defined as small eaters from their admission in EHPAD at the University Hospital of Dijon. This study will be carried out by a unique French multidisciplinary consortium that includes academics and health professionals, who will be able to specify the criteria defining the small eaters and to envisage suitable dietary strategies aiming to preserve their nutritional status and intestinal well-being. The final goal is to improve quality of life at home by prolonging autonomy and independence, and thus to deferring admission to an EHPAD for as long as possible. The objective of this study is to build a cohort of elderly small eaters and a cohort of elderly non small eaters. These patients will be followed over a period of one year. The evolution of the composition of the intestinal microbiota will be determined in order to establish the existing relations between the composition of digestive microbiota, the nutritional state, and cognitive and sensorimotor function.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 75
Healthy Volunteers: f
View:

• Person who has given oral consent and has not objected to being included in the study, or if necessary, oral consent of an appointed legal representative.

• A person over 75 years of age residing in an EHPAD who may be under guardianship or curatorship.

• A person over 75 years of age with a loss of appetite (i.e. a small eater) residing in an EHPAD, who may be under guardianship or curatorship.

Locations
Other Locations
France
Chu Dijon Bourgogne
RECRUITING
Dijon
Contact Information
Primary
Frédéric DALLE
frederic.dalle@chu-dijon.fr
0380295014
Time Frame
Start Date: 2023-06-13
Estimated Completion Date: 2028-06
Participants
Target number of participants: 140
Treatments
Non small eaters
Elderly subjects who are not malnourished
Small eaters
Elderly subjects with loss of appetite
Related Therapeutic Areas
Sponsors
Leads: Centre Hospitalier Universitaire Dijon

This content was sourced from clinicaltrials.gov