A Phase 1 Randomized, Observer-blind, Placebo-controlled, Dose-escalation Clinical Trial to Evaluate the Safety and Immunogenicity of rVSV∆G-MARV-GP Vaccine in Adults in Good General Health
A Phase 1 Randomized, Observer Blind, Placebo-controlled, Dose-escalation and dose expansion Clinical Trial to Evaluate the Safety and Immunogenicity of rVSV∆G-MARV-GP Vaccine in Adults in Good General Health
• Adults in good general health
• Participants who are 18 to 50 years of age
• Willing to comply with the requirements of the protocol and available for follow-up for the planned duration of the study
• Willing to undergo HIV testing, risk reduction counseling, and receive HIV test results
• All sexually active participants must consistently use male or female condoms with all sexual partners for 3 months following IP administration
• All individuals of childbearing potential engaging in sexual activity that could lead to pregnancy must commit to use an effective method of contraception from at least 2 weeks before and continue until 3 months following receipt of vaccine/placebo
• All individuals of childbearing potential must be willing to undergo urine pregnancy tests at time points indicated in the Schedule of Activities (SOA)
• All participants must be willing to forgo donation of blood or any other tissues from screening onward throughout the course of the study