Towards Optimal Treatment of Marfan Syndrome
Status: Completed
Location: See all (4) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY
The purpose of this study is to determine whether new magnetic resonance imaging techniques can be used as a biomarker of aortic disease severity in patients with Marfan syndrome.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 50
Healthy Volunteers: t
View:
• MFS patients with a known FBN1 mutation
• Between 18-50 years of age
Locations
Other Locations
Netherlands
Amsterdam UMC, location AMC
Amsterdam
University Medical Center Groningen
Groningen
Leiden University Medical Center
Leiden
Radboud University Medical Center
Nijmegen
Time Frame
Start Date: 2023-02-23
Completion Date: 2025-04-16
Participants
Target number of participants: 148
Treatments
Marfan Syndrome patients
Marfan Syndrome patients age 18-50 with a pathological FBN1 mutation
Healthy volunteers
Age and gender matched healthy control patients without a history of aortic disease.
Related Therapeutic Areas
Sponsors
Collaborators: Netherlands Organisation for Scientific Research
Leads: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)