• Patients must be ≥18 and ≤75 years of age at the time of consent.

• Patients with advanced metastatic solid tumors with clear pathological diagnosis, including melanoma, cervical cancer, head and neck squamous cell tumors, non-small cell lung cancer and breast cancer, etc.; while the expanded enrollment study plans to include those with melanoma, cervical cancer, and head and neck squamous cell tumors.

• At least one measurable target lesion even after resection, as defined by RECIST1.1.

• Lesions in previously irradiated areas (or other local therapy) should not be selected as target lesions, unless treatments was ≥3 months prior to Screening, and there has been demonstrated disease progression in that particular lesion.

• Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

• Patients must have an estimated life expectancy of ≥3 months.

• In the opinion of the Investigator, patients must be able to sign the ICF and complete all study-required procedures.

• Patients must have the following hematologic parameters, Coagulation functions and hepatic and renal function:

‣ White Blood Cell (WBC)≥2.5×10\^9/L；

⁃ Absolute Lymphocyte Count (ANC)≥1.5×10\^9/L;

⁃ Absolute Lymphocyte Count(ALC)≥0.7×10\^9/L;

⁃ Platelet≥100×10\^9/L；

⁃ International Normalized Ratio（INR）≤1.5×ULN;

⁃ Activated Partial Thromboplastin Time（APTT）≤1.5×ULN;

⁃ Serum Creatinine (Scr)≤1.5mg/dL (or 132.6μmol/L) or Creatinine Clearance≥60mL/min

⁃ Urinalysis: urine protein less than 2+, or 24-hour urine protein \<1g;

⁃ Alanine aminotransferase(AST/SGOT) ≤3×ULN;

⁃ Alanine aminotransferase (ALT/SGPT) ≤3×ULN;

⁃ Total Bilirubin(TBIL)≤1.5×ULN；

• Patients must have a washout period ≥ 4 weeks from prior anticancer therapy(ies) to the start of the planned preconditioning regimen, including targeted therapy, chemotherapy, immunotherapy: anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)/anti-PD-1, other monoclonal antibody (mAb), or vaccine Palliative radiation therapy.

• Patients of childbearing potential or their partners of childbearing potential must be willing to take the appropriate precaution to avoid pregnancy or fathering a child for the duration of the study and practice an approved, highly effective method of birth control during treatment and for 12 months after receiving the last protocol-related therapy.

⁃ Patients must have no contraindications for surgery or biopsy.

⁃ Patients (or legally authorized representative) must have the ability to understand the requirements of the study, have provided written informed consent as evidenced by signature on an ICF approved by an Institutional Review Board/Independent Ethics Committee (IRB/IEC), and agree to abide by the study restrictions and return to the site for the required assessments, including the OS Follow-up Period.