Identification of Metabolic Phenotypes Associated With Prognosis and Therapeutic Response in Patients With Melanoma
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This is a single centre, correlative, longitudinal, biomarker study that aims to describe the metabolic features of human melanoma using mass spectrometry.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Patient has provided written informed consent
• Male or female aged 18 years or older at written informed consent
• Presence of a known melanoma lesion requiring surgical excision or biopsy
• Patient is willing and able to comply with the protocol for the duration of the study including undergoing biopsies and receiving a stable isotope infusion (where applicable)
Locations
Other Locations
Australia
Peter Mac Callum Cancer Centre
RECRUITING
Melbourne
Contact Information
Primary
Aparna Rao
aparna.rao@petermac.org
+61385595000
Time Frame
Start Date: 2023-06-27
Estimated Completion Date: 2027-10
Participants
Target number of participants: 240
Treatments
Experimental: [U-13C]Glucose Infusion
A 13.3% solution of sterile, pyrogen-free \[U-13C\]glucose in sterile water will be infused intravenously rapidly over 10 minutes to a total dose of 8 grams (bolus dose). Then the infusion will change to a rate of 4 grams/ hour. The infusion will continue until the time of tumour excision or biopsy, planned 2-3 hours.
No_intervention: No [U-13C]Glucose Infusion
Blood and tissue samples to be collected for translational research studies, no other additional intervention.
Related Therapeutic Areas
Sponsors
Leads: Peter MacCallum Cancer Centre, Australia