Precision Medicine for L/GCMN and Melanoma 1 (Precis-mel 1)

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

The primary objective of this study is to create a highly multidimensional and multicentric database for melanoma that encompasses cohorts of children, adolescent and young adults. This database will be used to perform survival analysis and evaluate sentinel lymph node (SLNB) positivity in CAYA. The secondary objectives to be met are the following: * Adaptation and optimization of algorithms: work on optimizing existing precision medicine algorithms, which are currently being used in adult patient care, for their application within pediatric and young adult populations. * Implementation of transfer learning: given the limitations associated with pediatric and young adult data, the investigators intend to utilize transfer learning techniques. The study will employ a sequential waterfall methodology, whereby machine learning models trained on adult patient data will be fine-tuned using the more limited data from younger cohorts. * Integration of expert medical opinion: to integrate physician's scientific domain knowledge into the decision support system. This will be facilitated through the comprehensive examination of existing literature, as well as the evaluation of variable risk contributions within each patient group. * AI-based prognostic models: to develop artificial intelligence-based models for the quantitative prognosis of melanoma across the three age groups: adults, young adults, and children.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:

• \- Melanoma patients of any age with histopathological confirmed melanoma

Locations
Other Locations
Spain
Hospital Clínic de Barcelona (Dermatology service)
RECRUITING
Barcelona
Contact Information
Primary
Susana Puig Sardà, MD, PhD
spuig@clinic.cat
+34932275400
Backup
Adrián López Canosa, PhD
lopez64@recerca.clinic.cat
Time Frame
Start Date: 2024-03-01
Estimated Completion Date: 2026-11-30
Participants
Target number of participants: 6000
Treatments
Melanoma patients
The training dataset will consist of 6000 adult melanoma patients while the adaptation dataset for children, adolescents and young adults (CAYA) will be of N = 120.
Related Therapeutic Areas
Sponsors
Collaborators: Hospital Clinic of Barcelona
Leads: Fundacion Clinic per a la Recerca Biomédica

This content was sourced from clinicaltrials.gov