THE METFORMIN AND TRICHLOROACETIC ACID IN TREATMENT OF MELASMA

Who is this study for? Adult patients with Melasma
What treatments are being studied? Trichloroacetic Acid
Status: Unknown
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

Melasma is a chronic and relapsing acquired dyschromia due to an increased epidermal-melanin unit activity that affects sun-exposed areas mainly in women throughout the reproductive years. It is more common in women, accounting for 90% of all cases.The majority of patients are in third and fourth decades of their life. There are several risk factors that influence its appearance including genetic predisposition,exposure to heat and UV radiation, pregnancy, and exogenous hormones (such as oral contraceptives,thyroid hormones, and hormone replacement therapy). Other factors implicated are phototoxic drugs, anticonvulsant medications,and the use of certain cosmetics. Types of melasma are epidermal, dermal and mixed according to location of melanin.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• All patients above 18 years old with melasma.

• With Fitzpatrick skin phototypes ranging from Type III-V will recruited.

Locations
Other Locations
Egypt
Assuit University
RECRUITING
Asyut
Contact Information
Primary
Sahar Ismail, professor
saharsotohy@yahoo.com
01007074449
Backup
Radwa Bakr, lecturer
Radwabakr2011@hotmail.com
01119988115
Time Frame
Start Date: 2019-04-01
Completion Date: 2021-08
Participants
Target number of participants: 60
Treatments
Experimental: study Metformin 1000 mg
Experimental: study Metformin 500 mg
Placebo_comparator: control group
Sponsors
Leads: Assiut University

This content was sourced from clinicaltrials.gov