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Cognitive Remediation of Working Memory After Moderate to Severe Head Trauma. a SCED Study.

Status: Recruiting

Location: See location...

Intervention Type: Other

Study Type: Interventional

Study Phase: Not Applicable

SUMMARY

Patients with working memory deficits due to a moderate to severe head injury will undergo a 5 month protocol including cognitive remediation with numerous exercises, transcranial direct current stimulation (tDCS), and therapeutic education.

Eligibility

Participation Requirements

Sex: All

Minimum Age: 18

Maximum Age: 60

Healthy Volunteers: f

View:

• Moderate or severe head trauma, defined by an initial Glasgow score ≤ 12/15, duration of post-traumatic amnesia superior to 24 hours and/or the presence of abnormalities on brain imaging,

• Moderate or severe head trauma occurring within a period greater than or equal to 3 months,

• Working memory complaints assessed by the Working Memory Questionnaire,

• Patients with a working memory disorder in at least one of the following tests: Digit Memory subtest WAIS-IV (standard deviation ≤ -2) , PASAT (percentile ≤ 10), Brown-Peterson (standard deviation ≤ -2).

Locations

Other Locations

France

UH Toulouse

RECRUITING

Toulouse

Contact Information

Primary

Adeline Julien

julien.ade@chu-toulouse.fr

05 61 77 97 21

Backup

Clemence Le Bervet

lebervet.c@chu-toulouse.fr

Time Frame

Start Date: 2025-11-06

Estimated Completion Date: 2027-07-06

Participants

Target number of participants: 9

Treatments

Experimental: 4 weeks phase A arm

Phase A = Randomised duration of this phase : 4 weeks. each therapeutic therapeutic education sessions last 90 minutes.~Phase B = therapeutic education with tDCS for 4 weeks~Phase C = Cognitive remediation with tDCS for 4 weeks : Eight specific working memory remediation sessions will be carried out. These will be provided by a neuropsychologist. All cognitive remediation sessions will be individual, biweekly, lasting 1 hour 10 minutes for 4 weeks, for a total duration of 9 hours 20 minutes.~Phase D = follow-up

Experimental: 5 weeks phase A arm

Phase A = therapeutic education. Randomised duration of this phase : 5 weeks. each therapeutic therapeutic education sessions last 90 minutes.~Phase B = therapeutic education with tDCS for 4 weeks~Phase C = Cognitive remediation with tDCS for 4 weeks : Eight specific working memory remediation sessions will be carried out. These will be provided by a neuropsychologist. All cognitive remediation sessions will be individual, biweekly, lasting 1 hour 10 minutes for 4 weeks, for a total duration of 9 hours 20 minutes.~Phase D = follow-up

Experimental: 6 weeks phase A arm

Phase A = therapeutic education. Randomised duration of this phase : 6 weeks. each therapeutic therapeutic education sessions last 90 minutes.~Phase B = therapeutic education with tDCS for 4 weeks~Phase C = Cognitive remediation with tDCS for 4 weeks : Eight specific working memory remediation sessions will be carried out. These will be provided by a neuropsychologist. All cognitive remediation sessions will be individual, biweekly, lasting 1 hour 10 minutes for 4 weeks, for a total duration of 9 hours 20 minutes.~Phase D = follow-up

Related Therapeutic Areas

Memory Loss

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