Evaluation of Meningioma Mechanical Properties and Histological Features Using Three-Dimensional Magnetic Resonance Elastography
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test, Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This prospective single-center study aims to evaluate the feasibility and clinical utility of three-dimensional magnetic resonance elastography (3D MRE) in assessing tumor stiffness and adhesion in patients with meningioma undergoing surgical resection. By correlating preoperative MRE-derived stiffness and adhesion maps with intraoperative findings and histopathological features, the study seeks to determine whether MRE can serve as a noninvasive imaging biomarker for surgical planning, risk stratification, and prediction of tumor behavior.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: t
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• All patients undergoing meningeoma resection surgery are eligible for inclusion in the study cohort.
Locations
Other Locations
China
Shengjing Hospital
RECRUITING
Shenyang
Contact Information
Primary
Yu Shi, MD
18940259980@163.com
+86 189 4025 9980
Backup
Wen Cheng, MD
cmu071207@163.com
15040235535
Time Frame
Start Date: 2022-10-19
Estimated Completion Date: 2026-10-09
Participants
Target number of participants: 300
Treatments
Experimental: MRE-Guided Surgery Group
Participants in this group will undergo preoperative three-dimensional magnetic resonance elastography (3D MRE) in addition to routine MRI. MRE will be used to quantify tumor stiffness and generate a three-dimensional adhesion map. These imaging findings will be provided to the neurosurgical team prior to surgery to assist in planning the surgical approach and anticipating tumor consistency and adhesiveness. Intraoperative outcomes such as resection time, blood loss, and dissection difficulty will be recorded and analyzed in relation to preoperative MRE parameters.
Related Therapeutic Areas
Sponsors
Leads: Shengjing Hospital