Chronobiological Basis of Depression During the Menopause Transition

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to learn more about mood, sleep, and activity during menopause. The main question it aims to answer is: can mood and sleep dysfunction in menopause be improved by resetting misaligned circadian rhythm through one night of strategic sleep timing adjustment and two weeks of exposure to bright light at a certain time of day? Researchers will compare sleep timing (earlier vs. later) and bright white light exposure (morning or evening) to investigate the effect of melatonin levels on mood, sleep, and activity. Participants will 1) submit urine samples to measure melatonin levels, 2) be assigned to advance or delay their sleep for one night, 3) sit in front of a light box for 30 minutes per day (morning or evening) for 14 days, 4) complete questionnaires about their mood and sleep, and 5) wear a device that will measure their activity.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: f
View:

• Perimenopausal women with irregular menstrual cycles for at least 3 months

• Above age 18

• Experiencing at least moderate depression symptoms (i.e., score of at least 10 on PHQ-9)

Locations
United States
California
University of California San Diego Hillcrest Medical Center
RECRUITING
San Diego
Contact Information
Primary
Jennifer A Perrott, MSW
jperrott@health.ucsd.edu
(407) 619-9441
Backup
David Sommerfeld, Ph.D.
dsommerfeld@health.ucsd.edu
(407) 966-7703
Time Frame
Start Date: 2025-03-11
Estimated Completion Date: 2029-02-28
Participants
Target number of participants: 120
Treatments
Experimental: Experimental Group
Participants assigned to the experimental condition.
Active_comparator: Active Comparator Group
Participants assigned to the active comparator condition.
Related Therapeutic Areas
Sponsors
Leads: University of California, San Diego

This content was sourced from clinicaltrials.gov