The Influence of Estrogen on the Thermoregulatory Responses to Heat Stress in Pre and Postmenopausal Women
Status: Recruiting
Location: See location...
Intervention Type: Drug, Other
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group and age matched men. Aging and reproductive hormones, specifically estrogen, independently alter responses to heat stress. However, the combined effects of low estrogen following menopause and aging on the response to heat stress are unknown. In this study, the investigators will identify the role of estrogen in pre and post menopausal women on thermoregulatory responses to heat stress.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 42
Maximum Age: 64
Healthy Volunteers: t
View:
• Women ages 42-64
Locations
United States
Pennsylvania
Noll Laboratory
RECRUITING
University Park
Contact Information
Primary
W. Larry Kenney, Ph.D.
w7k@psu.edu
814-863-1672
Backup
Olivia K. Leach, MS
okl5046@psu.edu
Time Frame
Start Date: 2025-03-01
Estimated Completion Date: 2026-07-01
Participants
Target number of participants: 24
Treatments
Experimental: Premenopausal estrogen suppression
Participants take a cellulose placebo tablet for 4 days prior to baseline testing and continue until experimental visits are complete. Following completion of placebo testing, participants begin taking 400 mg/day Elagolix for 4 days prior to testing and continue until experimental visits are complete.
Experimental: Postmenopausal estrogen supplementation
Participants wear a transdermal estradiol patch or placebo patch for 5 days prior to testing and continue until experimental visits are complete. After 48 hr washout, participants then wear the alternative treatment for 5 days prior to testing until experimental visits are complete.
Related Therapeutic Areas
Sponsors
Leads: Penn State University