Urine Incontinence Occurrence and Sexual Hormones in Women With Chronic Spinal Cord Injury/Disease - a Pilot Study

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

There is a knowledge gap about the influence of the menstrual cycle on bladder function in women with spinal cord injury. So far, studies regarding urinary incontinence have primarily focused on women after menopause. It has become clear that a lack of the sex hormone estrogen, which occurs after menopause, can lead to urinary incontinence. During the course of the menstrual cycle, women also experience fluctuations in their sex hormones, particularly estrogen. The estrogen level is highest before ovulation and decreases afterwards. The investigators aim to explore whether this drop in hormone levels could lead to more frequent urinary incontinence during this phase. In order to offer the patients optimal treatment for urinary incontinence, it is important to understand the potential causes behind it. Participants will document their menstrual cycles and episodes of urinary incontinences over three menstrual cycles using a diary, and urine tests. This research project is a pilot study and is being conducted by Swiss Paraplegic Research at the Swiss Paraplegic Centre. The investigators are recruiting 12 participants who experience incontinence at least once a month and 12 participants who experience incontinence less frequently or not at all.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: f
View:

• women

• age ≥ 18 years

• chronic neurogenic bladder dysfunction due to acquired spinal cord injury

• regular menstrual cycle (26-30 days/cycle)

• written consent given

• UI group only: UI at least once per month

Locations
Other Locations
Switzerland
Swiss Paraplegic Center
RECRUITING
Nottwil
Contact Information
Primary
Jörg Krebs, Dr. med. vet. / PhD
joerg.krebs@paraplegie.ch
+41 41 939 59 46
Backup
Jürgen Pannek, Prof. Dr. med.
juergen.pannek@paraplegie.ch
Time Frame
Start Date: 2025-07-01
Estimated Completion Date: 2027-06-30
Participants
Target number of participants: 24
Treatments
Premenopausal women with spinal cord injury and urinary incontinence
Premenopausal women with spinal cord injury without urinary incontinence
Related Therapeutic Areas
Sponsors
Leads: Swiss Paraplegic Research, Nottwil

This content was sourced from clinicaltrials.gov