Effects of an Amylopectin Chromium Blend on Whole-Body Protein Kinetics and Glucose Control in Peri/Post-Menopausal Women
The goal of this study is to better understand how an amylopectin chromium blend may influence whole body protein balance in women during midlife, when hormonal changes can adversely affect protein metabolism and muscle maintenance. Continuous glucose monitoring will also be used to assess glycemic control over a 24-hour period. The main questions the study aims to answer are: * Does the use of an amylopectin chromium blend in peri- and post-menopausal women help to support positive protein balance * Can the affect be achieved using a concentrated dose Researchers will compare the nutritional supplement to a placebo (amylopectin alone) to see if the amylopectin chromium blend can promote positive protein balance. A concentrated dose of the supplement will also be evaluated for comparative effectiveness. Participants will: * Consume the nutritional supplement (standard or concentrated dose) or placebo acutely after a short resistance exercise bout * Complete four in-person visits, including the single-day intervention Results from this research may help guide future nutritional strategies to support healthy aging, muscle function, and overall metabolic health.
∙ Women aged 40-65 years who meet either of the following menstrual-history criteria:
• ≥ 60 days but \< 12 months of amenorrhea (late perimenopause)
• Women with ≥ 12 months of spontaneous amenorrhea (post-menopausal)
‣ No more than 3 days per week of structured physical activity
⁃ Provide voluntary signed and dated informed consent.
⁃ Be in good health and able to participate in an exercise bout as determined by assessment, medical history, and routine blood chemistries.
⁃ Between the of 40 and 65 years of age (inclusive).
⁃ Body Mass Index of 18.5-34.9 (inclusive).
⁃ Body weight of at least 110 pounds.
⁃ Normotensive (seated, resting systolic blood pressure \<140 mm Hg and diastolic blood pressure \< 90 mm Hg. If the first measurement is slightly elevated above these limits, the subject will be given a brief (5-minute) rest period, and two more measurements will be taken. The average of all three measurements will be used to determine eligibility.
⁃ Normal supine, resting heart rate (\<90 per minute).
⁃ Subject agrees to follow standardized controlled diet for 3 days and maintain existing dietary patterns on other days throughout the study period.
⁃ Subject is willing and able to comply with the study protocol.
⁃ Able to provide an adequate blood draw.
⁃ If a dietary supplement was initiated within the past month, the participant is willing to discontinue supplement use followed by a 2-week washout prior to participation in the study. Note: A generic multivitamin is allowed.
⁃ Refrain from caffeine, exercise, and alcohol for 24 hours prior, and fast for 10 hours prior to each visit.