The Role of Plasminogen Activator Inhibitor-1 (PAI-1), Tissue Plasminogen Activator (tPA), Tissue Factor Pathway Inhibitor (TFPI), and Endometrial Endothelial Cells in Uterine Hemostasis in Humans
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Phase 1/Phase 2
SUMMARY
The purpose of the study is to learn more about the role of blood clotting factor proteins and cells in menstrual (period) bleeding. The investigators are hoping to identify differences in these proteins and cells in the menstrual blood of individuals with heavy periods compared to menstruating individuals who do not have heavy periods.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 45
Healthy Volunteers: t
View:
• Regularly menstruating participants between 18-45 years of age
Locations
United States
Oregon
OHSU
RECRUITING
Portland
Contact Information
Primary
Women's Health Research Unit Department of Ob/Gyn
whru@ohsu.edu
503-494-3666
Time Frame
Start Date: 2023-07-12
Estimated Completion Date: 2026-07
Participants
Target number of participants: 70
Treatments
Active_comparator: Heavy Menstrual Bleeding
Participants with heavy menstrual bleeding will provide daily samples of menstrual blood for a single cycle and undergo a single endometrial biopsy for HEEC culture.
Active_comparator: Regular Mensural Bleeding
Participants with normal menstrual bleeding will provide daily samples of menstrual blood for a single cycle and undergo a single endometrial biopsy for HEEC culture.
Related Therapeutic Areas
Sponsors
Leads: Oregon Health and Science University