Investigation and Modulation of the Central Mu-Opioid Mechanism in Migraine (in Vivo)
This study investigates whether unilateral and bilateral non-invasive brain stimulation, given for 20 minutes/once per day for twenty days (M-F) can reduce migraine pain. Fourty patients will receive treatment (20 unilateral treatment, and 20 bilateral treatment), while twenty will receive a sham procedure. Another 20 Episodic Migraine patients will be recruited for the observational aim of the study which does not include brain stimulation.
• Male or female, aged 18 to 65 (inclusive)
• Patients must have Episodic migraines that started before the age of 50, and currently experience:
‣ Chronic migraine (ICHD-3-beta), headache occurring on 15 days/month for more than six months, which, on at least eight days/month, has the features of a migraine headache.
⁃ Episodic migraine (low frequency), specifically those with headache occurring less than 8 days/month.
• Willing to limit the introduction of new treatments and medications during the study period.