Discovering the Functional Role of the Glymphatic System in the Genesis of the Migraine Attack
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test, Drug, Device
Study Type: Observational
SUMMARY
This study aimed to investigate the role of the glymphatic system in the initiation of migraine attacks, using non-invasive magnetic resonance imaging techniques and a validated model of migraine induction by nitroglycerin administration. Secondarily, the relationship between the function of the glymphatic system during nitroglycerin-induced migraine attacks and sleep architecture and plasma levels of migraine-involved neuropeptides will be investigated.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 60
Healthy Volunteers: t
View:
⁃ For patients:
⁃ • Diagnosis of migraine, by the ICHD-3 criteria;
⁃ For both patients and healthy controls:
• Age between 18 and 60 years;
• Willing and able to comply with scheduled visits.
Locations
Other Locations
Italy
IRCCS San Raffaele Hospital
RECRUITING
Milan
Contact Information
Primary
Roberta Messina, MD, PhD
messina.roberta@hsr.it
00390226433944
Time Frame
Start Date: 2023-04-30
Estimated Completion Date: 2026-04-30
Participants
Target number of participants: 50
Treatments
Adult patients with migraine
Diagnosis of migraine, by the ICHD-3 criteria. Age between 18 and 60 years. Female and males. Right-handed
Healthy controls
Age between 18 and 60 years. Female and males. Right-handed
Related Therapeutic Areas
Sponsors
Leads: IRCCS San Raffaele