The Role of Furosemide Stress Test in Predicting Acute Kidney Injury Progression and Need for Renal Replacement Therapy in Patients Followed in the Intensive Care Clinic

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

AKI causes high mortality and morbidity, especially in critically ill patients, and prolongs the patient's stay in the intensive care unit. Due to the high morbidity and mortality associated with AKI, many researchers are studying several new biomarkers for earlier detection of AKI, determination of etiologies, and prediction of outcomes. However, the use of these new biomarkers may be limited due to reimbursement issues. In addition to the therapeutic role of furosemide in fluid balance, blood pressure control, and hypercalcemia management, Chawla et al. recommend the furosemide stress test (FST) as a tool to predict AKI progression. Designing a test that predicts the probability of AKI progression will help us make better decisions regarding the optimal timing of RRT initiation. In this study, we aimed to evaluate the feasibility of using the FST test in determining the progression of AKI in patients hospitalized in the intensive care unit and the need for RRT using the noninvasive procedure furosemide stress test.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Those who meet KDIGO AKI stage 1 and stage 2 criteria in the first 24 hours

• Those with sufficient fluid volume (CVP≥6 cmH20)

• Female and male patients over the age of 18 will be included in the study

Locations
Other Locations
Turkey
Gulhane Training and Research Hospital
RECRUITING
Ankara
Contact Information
Primary
mete e erdemir, intensive care specialist
meteerdemir@hotmail.com
+905066321175
Backup
gürhan T taşkın, Associate Professor
drgurhantaskin@gmail.com
+905057202781
Time Frame
Start Date: 2024-11-01
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 140
Treatments
Other: Furosemide stress test application in AKI stage 1-2 according to kdigo criteria
Among the patients included in the study, furosemide will be administered intravenously as a push at a dose of 1 mg/kg to patients who have not used furosemide in the last 7 days within the first 24 hours following ICU admission, and at a dose of 1.5 mg/kg to patients who have been exposed to furosemide. Patients who can pass 200 ml or more of urine within the first 2 hours after furosemide administration will be evaluated as having a positive furosemide stress test.
Related Therapeutic Areas
Sponsors
Leads: Gulhane Training and Research Hospital

This content was sourced from clinicaltrials.gov