Longitudinal Assessment of Brain Structure and Function in Juvenile Onset Huntington's Disease (JoHD)
Status: Recruiting
Location: See all (6) locations...
Study Type: Observational
SUMMARY
The goal of this observational study is to learn about brain development in Juvenile-onset Huntington's Disease (JoHD). The main questions it aims to answer are: * Is brain development different in JoHD than Adult-onset Huntington's Disease (AoHD)? * Can reliable biomarkers for JoHD be found in brain structure and function? Participants will be asked to complete cognitive tests, behavioral assessments, physical and neurologic evaluation, and MRI. Data collected will be compared to populations who are at-risk for HD and who have been diagnosed with HD as adults.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 6
Maximum Age: 30
Healthy Volunteers: f
View:
• Clinical diagnosis of JoHD
• Aged 6-30
Locations
United States
California
University of California Davis
NOT_YET_RECRUITING
Sacramento
Iowa
University of Iowa Hospitals and Clinics, Department of Psychiatry
RECRUITING
Iowa City
New York
Columbia University Medical Center
NOT_YET_RECRUITING
New York
Pennsylvania
Children's Hospital of Philadelphia with the University of Pennsylvania
RECRUITING
Philadelphia
Tennessee
Vanderbilt University Medical Center
NOT_YET_RECRUITING
Nashville
Texas
University of Texas Health Science Center at Houston
RECRUITING
Houston
Contact Information
Primary
Study Staff
kids-johd@uiowa.edu
866-514-0858
Backup
Sonia Slevinski, MS
sonia-slevinski@uiowa.edu
3193538529
Time Frame
Start Date: 2023-04-17
Estimated Completion Date: 2026-08-31
Participants
Target number of participants: 40
Treatments
JoHD
Children adolescents and young adults ages 6-30 who have been clinically diagnosed with Juvenile-onset Huntington's Disease
Related Therapeutic Areas
Sponsors
Collaborators: The University of Texas Health Science Center, Houston, Columbia University, UCL Queen Square Institute of Neurology, Children's Hospital of Philadelphia, George-Huntington-Institut GmbH, University of California, Davis
Leads: University of Iowa