Effects of Rhythmic Auditory Stimulation (RAS) on Gait in Parkinson Disease (PD) Patients With DBS
Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Participants will be asked to walk along with the metronome beats (RAS) during the participants' stimulation state (ON or OFF) for four minutes for each state. The researcher will collect the gait parameters (cadence, velocity, and stride length) of patients before, during, and after RAS in both DBS ON and OFF states. Using MDS-UPDRS, participants' gait patterns will be collected before and after RAS while both DBS is ON and OFF. Electrophysiological activity (local field potentials, LFPs) will be collected across all stages (pre, during, and post-RAS) of evaluation.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 89
Healthy Volunteers: f
View:
• Patients diagnosed with Parkinson disease (PD) (and)
• PD patients who implanted Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) with PerceptTM PC
Locations
United States
Maryland
Johns Hopkins School of Medicine
RECRUITING
Baltimore
Contact Information
Primary
Alexander Pantelyat, MD
apantel1@jhmi.edu
4105023290
Backup
Kyurim Kang, Ph.D.
kkang19@jhmi.edu
Time Frame
Start Date: 2023-08-01
Estimated Completion Date: 2026-04
Participants
Target number of participants: 10
Treatments
No_intervention: Pre RAS
After a 10-minute washout period, participants will receive the participants' optimized stimulation.~1. The participants will undergo assessments to measure gait parameters and patterns during stimulation ON and OFF (Pre-RAS) using the 10-meter walk (during a 2-minute walk) and MDS-UPDRS-III rating scale.~2. Electrophysiological activity (e.g., local field potentials, LFPs) will be collected before assessments.
Experimental: During RAS
1. The participants will walk to the metronome beats for four minutes (2 minutes for the same beats as baseline cadence and 2 minutes for 10% faster than baseline cadence) (RAS), and the participants' gait parameters will be recorded.~2. Electrophysiological activity (e.g., local field potentials, LFPs) will be collected.
No_intervention: Post RAS
The same assessment as the Pre-RAS will be conducted (Post-RAS).
Related Therapeutic Areas
Sponsors
Leads: Johns Hopkins University