Ocular Microtremor in Parkinson's Disease

Status: Recruiting
Location: See all (2) locations...
Study Type: Observational
SUMMARY

This is an exploratory, observational study that will use a novel handheld device - The iTremor ONE, which has been developed to rapidly, non-invasively assess and evaluate OMT frequency. This device uses incident laser technology directed at the sclera. PwPD who meet the inclusion criteria will participate in a home-based assessment involving cognitive, motor (using the UPDRS-III) and OMT measures. With OMT as the primary outcome, assessment with the iTremor is incredibly quick, taking just three seconds to obtain a reading. PwPD will be assessed both 'off' and on their anti-parkinsonian medication. 'Off' is defined as a 12Hr overnight washout period where participants are tested in the morning prior to their first dose. PwPD will also be invited into the laboratory to perform extensive cognitive assessments along with an assessment of balance, gait, and turning using wearable sensors. 40 PwPD, 20 with suspected PD, and 40 age-matched healthy control participants will be recruited for assessment of OMT. Ten PwPD will complete a test-retest reliability assessment at the same approx. time, exactly one week after their initial visit.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• People with suspected PD

• People with confirmed PD

• Healthy controls

• No history of head trauma

Locations
Other Locations
United Kingdom
Gateshead Health NHS Foundation Trust
NOT_YET_RECRUITING
Gateshead
Northumbria Healthcare NHS Trust
RECRUITING
North Shields
Contact Information
Primary
Lisa Graham, BSc
lisa4.graham@northumbria.ac.uk
+44 7972257940
Backup
Rosie Morris, PhD
rosie.e.morris@northumbria.ac.uk
Time Frame
Start Date: 2023-09-01
Estimated Completion Date: 2024-09-30
Participants
Target number of participants: 40
Treatments
suspPD
People referred to clinic with suspected PD
confPD
People with confirmed PD
HC
Healthy controls
Related Therapeutic Areas
Sponsors
Collaborators: Northumbria Healthcare NHS Foundation Trust, Gateshead Health NHS Foundation Trust
Leads: Northumbria University

This content was sourced from clinicaltrials.gov