Neurodegeneration and Neuronal Fluctuations in Lewy Body Disease and Alzheimer Disease
The purpose of this research study is to investigate how the brain, memory, thinking, and motor behavior change both in individuals with movement and/or cognitive disorders, as well as healthy individuals. Researchers will look at measurements of memory, thinking, brain wave and muscle activity, daily functioning, and brain scans to learn more about brain disorders such as Alzheimer disease and Lewy body disease.
• Use English as their primary language.
• Be willing to undergo health and cognitive assessments, as well as brain MRI and EEG study.
• Will be encouraged to have an available study partner (also called a co-participant) who is familiar with the participant's daily functioning.
• This study will be limited to healthy individuals, and patients who have a clinical diagnosis made by a board-certified neurologist of Lewy body disease or Alzheimer disease.
• All individuals must be capable of providing informed consent and complying with the trial procedures. Realizing the challenge of obtaining informed consent from cognitively impaired individuals, time is specifically scheduled to foster an informative, supportive interview with the participant and caregiver/legal guardian (typically a spouse or child according to Arizona law and IRB guidelines).
• Ongoing participation will be maintained by strict adherence to inclusion/exclusion criteria, clinical appropriateness (as determined by participant's physician and proxy/family), as well as by expressed wishes of family members/caregivers/proxy discussed at each study visit (as appropriate).
• All participants will receive copies of the signed ICFs (including signatures of those obtaining consent).
• All participants have the right to withdraw from the study at any time.