Role of the Subthalamic Nucleus in the Control of Movement: Physiopathology of Akinesia in Parkinson's Disease.
This program aims to understand the role of the subthalamic nucleus in the control of the movement in healthy humans and patients with Parkinson's disease, how the STN dysfunction contributes to akinesia and how the STN stimulation improves motor signs in PD patients .
• Diagnosis of idiopathic Parkinson's disease (according to the criteria of the United Kingdom Parkinson's Disease Society Brain Bank)
• Age between 18 and 70;
• Motor complications in the form of fluctuations in motor state or dyskinesias induced by dopaminergic therapy, despite medical treatment optimum;
• Other medical conditions that are stable or do not interfere with the procedure proposed;
• Excellent responsiveness to levodopa (UPDRS motor score improvement greater than 50% in the acute levodopa test)
• Brain MRI without abnormality
• Normality of biological examinations
• Person who has voluntarily and informedly agreed to participate in the study (signature of a written consent)
• Patient with social health insurance
• Diagnosis of idiopathic Parkinson's disease (according to the criteria of the United Kingdom Parkinson's Disease Society Brain Bank);
• Bilateral deep brain stimulation of the subthalamic nucleus for more than 1 year
• Age between 18 and 70;
• Person who has voluntarily and informedly agreed to participate in the study (signature of a written consent)
• Patient with social health insurance
• Age between 18 and 70 years old
• Normal neurological examination
• Person who voluntarily and informedly agreed to participate in the study (signature of a written consent)
• Patient with social health insurance