Genetics and Aerobic Exercise to Slow Parkinson's Disease (GEARS) Trial

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The proposed multi-site, Genetics and Aerobic Exercise to Slow PD (GEARS) Trial will, for the first time, determine the interplay between genetics and exercise in altering PD progression. In sum, 200 PD patients will be recruited from the Cleveland and Salt Lake City metro areas to participate in the Pedaling for Parkinson's (PFP) community-based exercise program. Participants will exercise at community-based sites 3x/week for 12 months. All participants will undergo genotyping using an array that includes the genome backbone and common risk variants associated to increase risk for multiple neurological disorders including PD.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Adult with a diagnosis of PD by a physician or physician extender

• Hoehn and Yahr stage I-III

• Demonstrate the ability to safely mount and dismount a stationary cycle

• Reliable transportation to the community exercise facility

• Smartphone device for activity data monitoring

• On a stable dose of anti-parkinsonian medication

Locations
United States
Ohio
The Cleveland Clinic
RECRUITING
Cleveland
Contact Information
Primary
Elizabeth Jansen, MPH
jansena@ccf.org
216-780-9160
Backup
Anson Rosenfeldt, DPT
rosenfa2@ccf.org
216-644-7617
Time Frame
Start Date: 2024-08-23
Estimated Completion Date: 2028-12-31
Participants
Target number of participants: 200
Treatments
Experimental: Interventional Arm
All participants will exercise in a community setting 3x/week for 12 months
Related Therapeutic Areas
Sponsors
Leads: Jay Alberts
Collaborators: National Institutes of Health (NIH)

This content was sourced from clinicaltrials.gov