Longitudinal Imaging of Striatal Synaptic Density and Volume in People With Premanifest Huntington's Disease.
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
AIM: to compare the sensitivity of SV2A PET and volumetric MRI to detect longitudinal striatal changes in premanifest HD. DESIGN: The investigators will include late premanifest HD mutations carriers and matched healthy controls. All subjects will undergo a clinical examination, with comprehensive assessment of motor and non-motor symptoms, and imaging evaluation consisting of 18F-SynVesT-1 PET and volumetric MRI at baseline and after 2 years.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 20
Maximum Age: 75
Healthy Volunteers: t
View:
• Age 20-75 years inclusive.
• Capacity to understand the informed consent form.
• HD mutation carriers:
‣ HTT (CAG)n ≥ 40
⁃ HD-ISS \< 2
⁃ CAP100 score \> 70
Locations
Other Locations
Belgium
University Hospitals Leuven
RECRUITING
Leuven
Time Frame
Start Date: 2024-12-04
Estimated Completion Date: 2028-12-31
Participants
Target number of participants: 35
Treatments
Experimental: Premanifest HD
At baseline and 2-year follow-up
Active_comparator: Healthy controls
At baseline and 2-year follow-up
Related Therapeutic Areas
Sponsors
Leads: Universitaire Ziekenhuizen KU Leuven