The Parkinson's Disease Case-Control Study: Gut Microbiome Study for Parkinson's Disease
The Parkinson's Disease Case-Control Study is a study of healthy volunteers and patients with Parkinson's disease aged 50-75 years living in Hangzhou, China. This study aims to systematically investigate the differences in intestinal fungi between patients and healthy volunteers, find the key strains, and explore the molecular mechanism of Parkinson's disease with multi-omics data. Another aim of this study is to explore the association between intestinal fungi and brain structure and function from the perspective of the gut-brain axis by combining brain image data.
⁃ (For PD patients)
• Men or women aged 50 to 75 years.
• Clinical diagnosis of Parkinson's disease (based on MDS Parkinson's disease diagnostic criteria)
• The patient must have at least two of the following symptoms: static tremor, bradykinesia, stiffness (which must include at least static tremor or bradykinesia); Or have asymmetrical resting tremors or asymmetrical bradykinesia.
• Able to provide informed consent.
⁃ (For healthy volunteers)
• Age (±2 years) and sex-matched healthy control individuals for each Parkinson's disease patient.
• Able to provide informed consent.