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Effects of Aerobic Training on Cerebrovascular Function, Cognitive Performance and Gait Parameters in Patients With Parkinson's Disease: A Randomized Controlled Trial

Status: Recruiting

Location: See location...

Intervention Type: Behavioral

Study Type: Interventional

Study Phase: Not Applicable

SUMMARY

This randomized controlled trial will investigate the effects of a 12-week supervised aerobic training program on cerebrovascular function, peripheral vascular health, cardiovascular autonomic modulation, cognition, non-motor symptoms, sleep, mood, gait biomechanics, quality of life, and body composition in patients with Parkinson's disease (Hoehn \& Yahr stages 1-3). Participants will be randomly allocated to aerobic training or usual care.

Eligibility

Participation Requirements

Sex: All

Minimum Age: 40

Healthy Volunteers: f

View:

• Clinical diagnosis of Parkinson's disease

• Hoehn \& Yahr stages 1-3

• Stable antiparkinsonian medication for at least 4 weeks

• Montreal Cognitive Assessment (MoCA) score ≥ 18

• Ability to walk independently (with or without assistive device)

• Medical clearance for participation in moderate-intensity exercise

Locations

Other Locations

Brazil

Associação Brasil Parkinson

RECRUITING

São Paulo

Contact Information

Primary

Raphael M Ritti-Dias, PhD

raphaelritti@gmail.com

+5519999406878

Backup

Hélcio Kanegusuku, PhD

helciokng@gmail.com

+55 11 99539-9557

Time Frame

Start Date: 2026-02-28

Estimated Completion Date: 2027-12-31

Participants

Target number of participants: 40

Treatments

Experimental: Aerobic Training

Participants will perform supervised aerobic training on a cycle ergometer, 3 times per week for 12 weeks, 40 minutes per session, at perceived exertion 12-13 on Borg scale.

Other: Usual Care

Participants will maintain their usual clinical care and daily activities without structured exercise intervention.

Related Therapeutic Areas

Movement Disorders

Parkinson's Disease

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