Using taVNS to Modulate Cardiovascular Function in Individuals With Neurologic Disease
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Phase 1
SUMMARY
The purpose of this study is to find out whether a type of gentle nerve stimulation, called transcutaneous auricular Vagus Nerve Stimulation (taVNS), can help improve how the body regulates heart rate and blood pressure in people with Parkinson's Disease (PD). Problems with heart rate and blood pressure control are common and can make it harder for people to exercise or do daily activities. By using this non-invasive form of nerve stimulation and testing how it affects the body's natural responses, this study hopes to learn if taVNS could be a helpful tool to support physical therapy and improve overall function.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:
• Diagnosis of idiopathic PD
• Stable medication for at least 4 weeks prior to the study
Locations
United States
Alabama
Wellness, Health and Research Facility at UAB
RECRUITING
Birmingham
Contact Information
Primary
Alexandra Evancho, DPT
amelgin@uab.edu
205-975-5221
Time Frame
Start Date: 2025-09-15
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 24
Treatments
Experimental: Group 1
Active taVNS on Visit 2, Sham taVNS on Visit 3. Active taVNS is delivered at 30 Hz, 250 µs, 0.1-4 mA for 15 minutes. Sham taVNS is delivered at 0 mA output for 15 minutes. A minimum washout period of 48 hours will be observed between visits.
Experimental: Group 2
Sham taVNS on Visit 2, Active taVNS on Visit 3. Active taVNS is delivered at 30 Hz, 250 µs, 1-4 mA for 15 minutes. Sham taVNS is delivered at 0 mA output for 15 minutes. A minimum washout period of 48 hours will be observed between visits
Related Therapeutic Areas
Sponsors
Leads: University of Alabama at Birmingham