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Artificial Intelligence-Driven Freezing Of Gait Detection in the Home: Investigating How Free-living Activities Affect the Algorithm

Status: Recruiting
Location: See all (3) locations...
Study Type: Observational
SUMMARY

Freezing of gait (FOG) is a debilitating symptom of Parkinson's disease increases the risk of falling. Despite being a common symptom, it is still difficult to evaluate freezing of gait quickly and accurately. Currently, the gold-standard method to determine the severity of FOG is a manual analysis of video footage by an experienced assessor, collected during standardized FOG-provoking walking tests. Because this is a very time-intensive process, where different assessors sometimes obtain different results, our team at KU Leuven have developed an artificial-intelligent (AI) algorithm trained to identify FOG episodes based on wearable inertial measurement unit (IMU) sensor data. The AI algorithm has already undergone initial validation during laboratory testing, yielding promising results. The aim of this study is to investigate whether the AI algorithm can accurately detect FOG episodes in a less controlled environment, namely the home environment. In a second phase, the investigators will also use the collected data to improve the AI algorithm for automated FOG detection in the home. Finally, the investigators want to explore whether the AI algorithm can detect FOG in real-time.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

⁃ For all participants

• Voluntary written informed consent of the participant has been obtained prior to any study-related procedures, except the non-recorded pre-screening questions;

• At least 18 years of age at the time of signing the Informed Consent Form (ICF);

• Person is cognitively able to follow and understand instructions and provide voluntary written informed consent;

• Person is able to walk for short distances (± 10 meters) independently, with- or without use of a walking aid;

• Person does not live in a temporary or permanent care facility.

⁃ For participants with PD:

• Clinical diagnosis of Parkinson's disease (PD) made by a neurologist according to the Movement Disorders Society guidelines;

• Person self-reports to experience daily FOG (for recruitment of freezers only);

• Person is willing to temporarily delay the morning anti-Parkinsonian medication during the standardized assessment visit.

Locations
Other Locations
Belgium
Department of Rehabilitation Sciences
RECRUITING
Leuven
Germany
Sports Science and Neurorehabilitation
NOT_YET_RECRUITING
Hamburg
Israel
Center for the study of movement, cognition and mobility
NOT_YET_RECRUITING
Tel Aviv
Time Frame
Start Date: 2025-09-22
Estimated Completion Date: 2027-06
Participants
Target number of participants: 126
Treatments
Freezers
Patients with Parkinson's disease who self-report to experience Freezing of Gait daily.
Non-freezers
Patients with Parkinson's disease who do not experience Freezing of Gait.
Healthy controls
Healthy older adults
Related Therapeutic Areas
Sponsors
Collaborators: Medical School Hamburg, Tel Aviv Medical Center, Michael J. Fox Foundation for Parkinson's Research
Leads: KU Leuven

This content was sourced from clinicaltrials.gov