A Phase 3, Two-Stage, Randomized, Multicenter, Open-Label Study Comparing Mezigdomide (CC-92480), Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Subjects With Relapsed or Refractory Multiple Myeloma (RRMM): SUCCESSOR-1
Status: Recruiting
Location: See all (263) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
The purpose of this study is to compare the efficacy and safety of mezigdomide (CC-92480), bortezomib and dexamethasone (MeziVd) versus pomalidomide, bortezomib and dexamethasone (PVd) in participants with relapsed or refractory multiple myeloma (RRMM) who received between 1 to 3 prior lines of therapy and who have had prior lenalidomide exposure.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
⁃ \- Participant has documented diagnosis of MM and measurable disease, defined as any of the following:.
⁃ i) M-protein ≥ 0.5 grams per deciliter (g/dL) by serum protein electrophoresis (sPEP) or.
⁃ ii) M-protein ≥ 200 milligrams (mg) per 24-hour urine collection by urine protein electrophoresis (uPEP).
⁃ iii) For participants without measurable disease in sPEP or uPEP: serum free light chain (sFLC) levels \> 100 mg/L (10 mg/dL) involved light chain and an abnormal kappa/lambda FLC ratio.
• Participants received 1 to 3 prior lines of antimyeloma therapy.
• Participants achieved minimal response \[MR\] or better to at least 1 prior antimyeloma therapy.
Locations
United States
California
Cancer and Blood Specialty Clinic
RECRUITING
Los Alamitos
Sharp Memorial Hospital
RECRUITING
San Diego
Local Institution - 0273
COMPLETED
West Hollywood
Colorado
Local Institution - 0381
NOT_YET_RECRUITING
Aurora
Connecticut
UConn Health
RECRUITING
Farmington
Local Institution - 0208
WITHDRAWN
New Haven
Florida
Advanced Research
RECRUITING
Coral Springs
Florida Cancer Specialists - South
RECRUITING
Fort Myers
Florida Cancer Specialists - North
RECRUITING
St. Petersburg
Florida Cancer Specialists - East
RECRUITING
West Palm Beach
Georgia
University Cancer Blood Ctr
RECRUITING
Athens
Local Institution - 0048
WITHDRAWN
Marietta
Kansas
Local Institution - 0330
COMPLETED
Garden City
University of Kansas Medical Center
RECRUITING
Westwood
Louisiana
Our Lady of the Lake RMC
RECRUITING
Baton Rouge
Local Institution - 0255
ACTIVE_NOT_RECRUITING
New Orleans
Local Institution - 0385
NOT_YET_RECRUITING
Shreveport
Massachusetts
Dana-Farber Cancer Institute
RECRUITING
Boston
Maryland
Sinai Hospital Of Baltimore
RECRUITING
Baltimore
Michigan
University of Michigan
RECRUITING
Ann Arbor
Henry Ford Hospital
RECRUITING
Detroit
Minnesota
Minnesota Oncology Hematology, P.A.
RECRUITING
Minneapolis
Mississippi
Hattiesburg Clinic Hematology/Oncology
RECRUITING
Hattiesburg
Local Institution - 0242
WITHDRAWN
Jackson
North Carolina
Duke Cancer Institute
RECRUITING
Durham
New Jersey
Astera Cancer Care
RECRUITING
East Brunswick
Local Institution - 0363
NOT_YET_RECRUITING
Ridgewood
New Mexico
University of New Mexico Comprehensive Cancer Center
RECRUITING
Albuquerque
New York
Local Institution - 0245
WITHDRAWN
Buffalo
Northwell Health/ RJ Zuckerberg Cancer Center
RECRUITING
Lake Success
Local Institution - 0373
COMPLETED
New Hyde Park
Local Institution - 0371
COMPLETED
New York
Rochester General Hospital
RECRUITING
Rochester
New York Cancer and Blood Specialists
RECRUITING
Shirley
Local Institution - 0372
COMPLETED
The Bronx
Local Institution - 0274
WITHDRAWN
Williamsville
Ohio
Oncology Hematology Care
RECRUITING
Cincinnati
Cleveland Clinic
RECRUITING
Cleveland
Fairview Hospital
RECRUITING
Cleveland
Cleveland Clinic - Hillcrest Hospital
RECRUITING
Mayfield Heights
Pennsylvania
Lehigh Valley Health Network
RECRUITING
Allentown
Local Institution - 0264
COMPLETED
York
Tennessee
The West Clinic, PLLC dba West Cancer Center
RECRUITING
Germantown
Texas
Texas Oncology - West Texas
RECRUITING
Abilene
University of Texas MD Anderson Cancer Center
RECRUITING
Houston
Mays Cancer Center
RECRUITING
San Antonio
Texas Oncology - San Antonio
RECRUITING
San Antonio
Utah
Utah Cancer Specialists
RECRUITING
Salt Lake City
Virginia
Hematology Oncology Associates of Fredericksburg
RECRUITING
Fredericksburg
Virginia Oncology Associates
RECRUITING
Norfolk
Blue Ridge Cancer Care
RECRUITING
Roanoke
Washington
Local Institution - 0293
WITHDRAWN
Seattle
VA Puget Sound Health Care System
RECRUITING
Seattle
Local Institution - 0097
WITHDRAWN
Spokane
Northwest Cancer Specialists, P.C.
RECRUITING
Vancouver
Wisconsin
Local Institution - 0220
WITHDRAWN
Madison
Other Locations
Argentina
Local Institution - 0213
ACTIVE_NOT_RECRUITING
Buenos Aires
Local Institution - 0214
ACTIVE_NOT_RECRUITING
Buenos Aires
Local Institution - 0318
ACTIVE_NOT_RECRUITING
Chivilcoy
Local Institution - 0249
ACTIVE_NOT_RECRUITING
Córdoba
Local Institution - 0200
ACTIVE_NOT_RECRUITING
Rosario
Local Institution - 0248
COMPLETED
S3000epv
Local Institution - 0239
ACTIVE_NOT_RECRUITING
Viedma
Australia
Local Institution - 0327
ACTIVE_NOT_RECRUITING
Birtinya
Local Institution - 0221
ACTIVE_NOT_RECRUITING
Box Hill
Local Institution - 0055
ACTIVE_NOT_RECRUITING
Liverpool
Local Institution - 0002
ACTIVE_NOT_RECRUITING
Melbourne
Local Institution - 0003
ACTIVE_NOT_RECRUITING
Melbourne
Local Institution - 0040
ACTIVE_NOT_RECRUITING
Nedlands
Local Institution - 0004
ACTIVE_NOT_RECRUITING
Waratah
Local Institution - 0017
ACTIVE_NOT_RECRUITING
Wollongong
Austria
Universitätsklinikum Krems
RECRUITING
Krems
LKH Hochsteiermark - Standort Leoben
RECRUITING
Leoben
Universitätsklinikum St. Pölten
RECRUITING
Sankt Pölten
Hanusch-Krankenhaus
RECRUITING
Vienna
Klinik Ottakring
RECRUITING
Vienna
Belgium
ZNA Cadix
RECRUITING
Antwerp
Ziekenhuis Oost-Limburg, Campus St.-Jan
RECRUITING
Genk
UZ Gent
RECRUITING
Ghent
AZ Nikolaas
RECRUITING
Sint-niklaas
Brazil
Hospital Amaral Carvalho
RECRUITING
Jaú
Instituto Joinvilense de Hematologia e Oncologia
RECRUITING
Joinville
Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa
RECRUITING
Porto Alegre
Americas Centro de Oncologia Integrado
RECRUITING
Rio De Janeiro
Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador
RECRUITING
Salvador
Clínica Médica São Germano S/S Ltda
RECRUITING
São Paulo
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
RECRUITING
São Paulo
Canada
Local Institution - 0225
ACTIVE_NOT_RECRUITING
Greenfield Park
Local Institution - 0174
ACTIVE_NOT_RECRUITING
Montreal
Local Institution - 0222
ACTIVE_NOT_RECRUITING
Québec
Chile
Local Institution - 0329
ACTIVE_NOT_RECRUITING
Santiago
Local Institution - 0387
ACTIVE_NOT_RECRUITING
Santiago
Local Institution - 0332
ACTIVE_NOT_RECRUITING
Viña Del Mar
China
Local Institution - 0062
ACTIVE_NOT_RECRUITING
Beijing
Local Institution - 0141
COMPLETED
Beijing
Local Institution - 0150
COMPLETED
Beijing
Local Institution - 0165
COMPLETED
Beijing
Local Institution - 0147
ACTIVE_NOT_RECRUITING
Changsha
Local Institution - 0155
ACTIVE_NOT_RECRUITING
Changsha
Local Institution - 0144
ACTIVE_NOT_RECRUITING
Chongqing
Local Institution - 0356
NOT_YET_RECRUITING
Deyang
Local Institution - 0117
ACTIVE_NOT_RECRUITING
Guangzhou
Local Institution - 0168
WITHDRAWN
Guangzhou
Local Institution - 0177
ACTIVE_NOT_RECRUITING
Guangzhou
Local Institution - 0151
WITHDRAWN
Hangzhou
Local Institution - 0202
ACTIVE_NOT_RECRUITING
Kunming
Local Institution - 0348
ACTIVE_NOT_RECRUITING
Linhai
Local Institution - 0412
COMPLETED
Liuchow
Local Institution - 0395
COMPLETED
Luoyang
Local Institution - 0111
ACTIVE_NOT_RECRUITING
Nanjing
Local Institution - 0240
ACTIVE_NOT_RECRUITING
Nanning
Local Institution - 0112
ACTIVE_NOT_RECRUITING
Ningbo
Local Institution - 0169
COMPLETED
Qingdao
Local Institution - 0114
ACTIVE_NOT_RECRUITING
Shanghai
Local Institution - 0350
ACTIVE_NOT_RECRUITING
Shanghai
Local Institution - 0287
ACTIVE_NOT_RECRUITING
Shenyang
Local Institution - 0238
ACTIVE_NOT_RECRUITING
Shenzhen
Local Institution - 0254
ACTIVE_NOT_RECRUITING
Shijiazhuang
Local Institution - 0164
ACTIVE_NOT_RECRUITING
Taiyuan
Local Institution - 0176
ACTIVE_NOT_RECRUITING
Taiyuan
Local Institution - 0119
ACTIVE_NOT_RECRUITING
Tianjin
Local Institution - 0353
NOT_YET_RECRUITING
Ürümqi
Local Institution - 0149
ACTIVE_NOT_RECRUITING
Wenzhou
Local Institution - 0142
ACTIVE_NOT_RECRUITING
Wuhan
Local Institution - 0139
ACTIVE_NOT_RECRUITING
Wuxi
Local Institution - 0110
COMPLETED
Xi'an
Local Institution - 0148
ACTIVE_NOT_RECRUITING
Xi'an
Local Institution - 0237
ACTIVE_NOT_RECRUITING
Xiamen
Local Institution - 0113
ACTIVE_NOT_RECRUITING
Zhengzhou
Finland
Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus)
RECRUITING
Helsinki
Kuopion Yliopistollinen Sairaala
RECRUITING
Kuopio
France
Centre Hospitalier Universitaire Estaing
RECRUITING
Clermont-ferrand
Hopital Claude Huriez - CHU de Lille
RECRUITING
Lille
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren
RECRUITING
Limoges
Centre Leon Berard
RECRUITING
Lyon Cedex08
Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu
RECRUITING
Nantes
Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire Carémeau
RECRUITING
Nîmes
Hôpital Saint Antoine
RECRUITING
Paris
CHU Bordeaux Haut-Leveque
RECRUITING
Pessac
Institut de cancérologie Strasbourg Europe (ICANS)
RECRUITING
Strasbourg
Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau
RECRUITING
Tours
Germany
Universitätsklinikum Aachen
RECRUITING
Aachen
Sozialstiftung Bamberg
RECRUITING
Bamberg
Universitätsklinikum Bonn
RECRUITING
Bonn
Gemeinschaftspraxis Hämatologie - Onkologie Freiberg-Richter, Jacobasch, Illmer, Wolf
RECRUITING
Dresden
Marien Hospital Düsseldorf
RECRUITING
Düsseldorf
Local Institution - 0396
NOT_YET_RECRUITING
Erfurt
Asklepios Altona
RECRUITING
Hamburg
Universitaetsklinikum Hamburg-Eppendorf
RECRUITING
Hamburg
Praxis Onkologie am Raschplatz
RECRUITING
Hanover
Universitaetsklinikum Schleswig-Holstein Campus Kiel
RECRUITING
Kiel
Universitätsklinikum Marburg
RECRUITING
Marburg
TUM Klinikum
RECRUITING
München
Klinikum Traunstein
RECRUITING
Traunstein
Universitaetsklinikum Tuebingen
RECRUITING
Tübingen
Medizinisches Versorgungszentrum
RECRUITING
Weiden
Gemeinschaftspraxis Dres. med. Björn Schöttker & Dominik Pretscher
RECRUITING
Würzburg
Greece
Alexandra General Hospital of Athens
RECRUITING
Athens
Evangelismos General Hospital of Athens
RECRUITING
Athens
G. Papanikolaou General Hospital
RECRUITING
Thessaloniki
India
HCG Aastha Cancer Centre
RECRUITING
Ahmedabad
KLES Dr. Prabhakar Kore Hospital & M.R.C
RECRUITING
Belagavi
Marengo Asia Hospitals Gurugram
RECRUITING
Gurugram
Christian Medical College & Hospital
RECRUITING
Ludhiana
Meenakshi Mission Hospital and Research Centre
RECRUITING
Madurai
Mumbai Oncocare Centre - Nanachowk
RECRUITING
Mumbai
Jawaharlal Institute Of Postgraduate Medical Education And Research
RECRUITING
Puducherry
Tata Memorial Centre - Homi Bhabha Cancer Hospital
RECRUITING
Varanasi
Ireland
Cork University Hospital
RECRUITING
Cork
St. James's Hospital
RECRUITING
Dublin
University College Hospital - Galway
RECRUITING
Galway
Local Institution - 0251
WITHDRAWN
Limerick
Israel
Rambam Health Care Campus
RECRUITING
Haifa
Hadassah Medical Center - Do Not Use - Duplicate Facility
RECRUITING
Jerusalem
Meir Medical Center
RECRUITING
Kfar Saba
Rabin Medical Center
RECRUITING
Peatch Tikva
Sheba Medical Center
RECRUITING
Ramat Gan
Sourasky Medical Center
RECRUITING
Tel Aviv
Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
RECRUITING
Bologna
Policlinico G. Rodolico
RECRUITING
Catania
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori
RECRUITING
Meldola
Fondazione IRCCS Policlinico San Matteo
RECRUITING
Pavia
Azienda Ospedaliera Sant'Andrea
RECRUITING
Rome
Japan
Chiba University Hospital
RECRUITING
Chiba
Japanese Red Cross Fukuoka Hospital
RECRUITING
Fukuoka
National Hospital Organization Kyushu Medical Center
RECRUITING
Fukuoka
Mito Medical Center
RECRUITING
Higashiibaraki
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
RECRUITING
Hiroshima
Saitama Medical University Hospital
RECRUITING
Iruma
Nihon University Itabashi Hospital
RECRUITING
Itabashiku
Shonan Kamakura General Hospital
RECRUITING
Kamakura
National Cancer Center Hospital East
RECRUITING
Kashiwa
Japan Community Healthcare Organization Kyushu Hospital
RECRUITING
Kitakyushu-shi
Dokkyo Medical University Saitama Medical Center
RECRUITING
Koshigaya
Kumamoto University
RECRUITING
Kumamoto
Shizuoka Cancer Center
RECRUITING
Nagaizumi-cho,sunto-gun
The Japanese Red Cross Nagasaki Genbaku Hospital
RECRUITING
Nagasaki
National Hospital Organization Hokkaido Cancer Center
RECRUITING
Sapporo
Iwate Medical University Hospital
RECRUITING
Shiwa-gun Yahaba-cho
Japanese Red Cross Medical Center
RECRUITING
Tokyo
The Jikei University Hospital
RECRUITING
Tokyo
New Zealand
Local Institution - 0334
WITHDRAWN
Auckland
Local Institution - 0369
ACTIVE_NOT_RECRUITING
Auckland
Local Institution - 0340
ACTIVE_NOT_RECRUITING
Dunedin
Local Institution - 0335
ACTIVE_NOT_RECRUITING
Tauranga
Poland
Pratia Onkologia Katowice
RECRUITING
Katowice
Local Institution - 0325
NOT_YET_RECRUITING
Krakow
Local Institution - 0346
WITHDRAWN
Skórzewo
Local Institution - 0292
COMPLETED
Słupsk
Local Institution - 0224
COMPLETED
Torun
Local Institution - 0250
COMPLETED
Warsaw
Portugal
Hospital de Braga
RECRUITING
Braga
Champalimaud Foundation
RECRUITING
Lisbon
Instituto Português de Oncologia do Porto Francisco Gentil, EPE
RECRUITING
Porto
Puerto Rico
Local Institution - 0355
WITHDRAWN
San Juan
Republic of Korea
Local Institution - 0106
WITHDRAWN
Busan
Pusan National University Hospital
RECRUITING
Busan
Chonnam National University Hwasun Hospital
RECRUITING
Hwasun
Local Institution - 0103
WITHDRAWN
Hwasun
Local Institution - 0102
WITHDRAWN
Seongnam
Seoul National University Bundang Hospital
RECRUITING
Seongnam
Asan Medical Center
RECRUITING
Seoul
Local Institution
NOT_YET_RECRUITING
Seoul
Local Institution - 0100
WITHDRAWN
Seoul
Local Institution - 0101
WITHDRAWN
Seoul
Local Institution - 0104
WITHDRAWN
Seoul
Local Institution - 0105
WITHDRAWN
Seoul
Samsung Medical Center
RECRUITING
Seoul
Seoul National University Hospital
RECRUITING
Seoul
Severance Hospital, Yonsei University Health System
RECRUITING
Seoul
The Catholic Univ. of Korea Seoul St. Mary's Hospital
RECRUITING
Seoul
Romania
Fundeni Clinical Institute
RECRUITING
Bucharest
Institutul Oncologic Cluj
RECRUITING
Cluj-napoca
Institutul Regional de Oncologie Iasi
RECRUITING
Iași
South Africa
Groote Schuur Hospital
RECRUITING
Cape Town
Netcare Pretoria East Hospital
RECRUITING
Centurion
Haemalife
RECRUITING
Kuilsriver
Constantiaberg Haematology
RECRUITING
Plumstead
Spain
Hospital Clínic de Barcelona
RECRUITING
Barcelona
Local Institution - 0073
WITHDRAWN
Barcelona
Hospital San Pedro de Alcantara
RECRUITING
Cáceres
Complejo Asistencial Universitario de León - Hospital de León
RECRUITING
León
Hospital Universitario 12 de Octubre
RECRUITING
Madrid
Hospital Costa del Sol
RECRUITING
Marbella
Local Institution - 0182
WITHDRAWN
Marbella
Hospital General Universitario Morales Meseguer
RECRUITING
Murcia
Hospital Universitari Son Espases
RECRUITING
Palma
Local Institution - 0183
WITHDRAWN
Palma
Turkey
Ankara University Health Practice and Research Hospitals
RECRUITING
Ankara
Liv Hospital Ankara
RECRUITING
Ankara
Istanbul University, Istanbul Faculty of Medicine
RECRUITING
Istanbul
Ege Universitesi Hastanesi
RECRUITING
Izmir
Erciyes Universitesi Tıp Fakultesi Hastaneleri
RECRUITING
Kayseri
Ondokuz Mayıs Universitesi
RECRUITING
Samsun
United Kingdom
Lanarkshire NHS Trust - Monklands Hospital
RECRUITING
Airdrie
Barnet Hospital
RECRUITING
Barnet
Addenbrooke's Hospital
RECRUITING
Cambridge
Leicester Royal Infirmary
RECRUITING
Leicester
Hammersmith Hospital
RECRUITING
London
King's College Hospital
RECRUITING
London
Freeman Hospital
RECRUITING
Newcastle Upon Tyne
Royal Stoke University Hospital
RECRUITING
Stoke-on-trent
The Royal Cornwall Hospital
RECRUITING
Truro
Contact Information
Primary
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
Clinical.Trials@bms.com
855-907-3286
Backup
First line of the email MUST contain NCT # and Site #.
Time Frame
Start Date: 2022-09-20
Estimated Completion Date: 2033-11-30
Participants
Target number of participants: 810
Treatments
Experimental: MeziVd (mezigdomide, bortezomib and dexamethasone)
Experimental: PVd (pomalidomide, bortezomib and dexamethasone)
Related Therapeutic Areas
Sponsors
Leads: Celgene