A Phase 3 Randomized Study Comparing JNJ-79635322 Versus Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma After 1 to 3 Prior Lines of Therapy, Including an Anti-CD38 Antibody and Lenalidomide
Status: Recruiting
Location: See all (146) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
The purpose of this study is to evaluate how well JNJ-79635322 works when compared with teclistamab.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Documented diagnosis of multiple myeloma (MM) as defined by the criteria below: a. MM diagnosis according to the international myeloma working group (IMWG) diagnostic criteria, b. Measurable disease at screening as assessed by central laboratory
• Received 1 to 3 prior lines of antimyeloma therapy, including an anti-cluster of differentiation (CD) 38 antibody and lenalidomide
• Have an eastern cooperative oncology group (ECOG) performance status of 0 to 2 at screening and immediately before the first dose of study medication
• Have clinical laboratory values meeting the criteria specified in the protocol during the screening and within 1 day of the start of administration of study treatment
Locations
United States
Alabama
Alabama Oncology
RECRUITING
Birmingham
Arkansas
Highlands Oncology Group
RECRUITING
Springdale
Arizona
Mayo Clinic 1
RECRUITING
Phoenix
California
Beverly Hills Cancer Center Clinical Research Advisors LLC
RECRUITING
Beverly Hills
UC Irvine Health Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITING
Irvine
Valkyrie Clinical Trials
RECRUITING
Los Angeles
University of California Irvine Medical Center
RECRUITING
Orange
Colorado
Colorado Blood Cancer Institute
RECRUITING
Denver
Connecticut
University of Connecticut Health Center
RECRUITING
Farmington
Florida
Mayo Clinic Jacksonville
RECRUITING
Jacksonville
Memorial Cancer Institute
RECRUITING
Pembroke Pines
Georgia
Emory University
RECRUITING
Atlanta
Iowa
University of Iowa Hospitals and Clinics
RECRUITING
Iowa City
Mission Cancer Blood University of Iowa Health Care
RECRUITING
Waukee
Illinois
Rush University System for Health
RECRUITING
Chicago
Indiana
Franciscan Health
RECRUITING
Indianapolis
Kentucky
Norton Cancer Institute
RECRUITING
Louisville
Louisiana
LSU Health Feist Weiller Cancer Center
RECRUITING
Shreveport
Michigan
Karmanos Cancer Institute
RECRUITING
Detroit
Minnesota
University Of Minnesota Medical Center
RECRUITING
Minneapolis
Mayo Clinic
RECRUITING
Rochester
Nebraska
Nebraska Cancer Specialists
RECRUITING
Omaha
New Jersey
Astera Cancer Care
RECRUITING
East Brunswick
New Mexico
Christus St. Vincent Regional Cancer Center
RECRUITING
Santa Fe
New York
New York Oncology Hematology
RECRUITING
Albany
Laura & Isaac Perlmutter Cancer Center at NYU Langone Hospital - Long Island
RECRUITING
Mineola
NYU Langone Health Manhattan
RECRUITING
New York
New York Cancer and Blood Specialists
RECRUITING
Shirley
Ohio
Gabrail Cancer Center
RECRUITING
Canton
The Christ Hospital
RECRUITING
Cincinnati
Dayton Physicians Network Urology
RECRUITING
Dayton
South Carolina
Bon Secours Saint Francis Cancer Center
RECRUITING
Greenville
Texas
Baylor University Medical Center
RECRUITING
Dallas
Joe Arrington Cancer Research Treatment Center
RECRUITING
Lubbock
Utah
Utah Cancer Specialists
RECRUITING
Salt Lake City
Other Locations
Australia
St Vincent s Hospital Sydney
RECRUITING
Darlinghurst
Austin Hospital
RECRUITING
Heidelberg
Macquarie University Hospital
RECRUITING
Macquarie University
Box Hill Hospital
RECRUITING
Melbourne
Port Macquarie Base Hospital
RECRUITING
Port Macquarie
Brazil
Hospital Erasto Gaertner- Liga Paranaense de Combate ao Cancer
RECRUITING
Curitiba
Grupo ELORA Centro de Pesquisa e Ensino em Saude de Santa Catarina
RECRUITING
Florianópolis
Instituto Joinvilense de Hematologia e Oncologia Ltda Centro de Hematologia e Oncologia
RECRUITING
Joinville
Irmandade Santa Casa de Misericordia de Porto Alegre
RECRUITING
Porto Alegre
Funfarme Sjrp
RECRUITING
São José Do Rio Preto
Clinica Medica Sao Germano LTDA
RECRUITING
São Paulo
Real e Benemerita Associacao Portuguesa de Beneficencia
RECRUITING
São Paulo
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
RECRUITING
São Paulo
China
Peking Union Medical College Hospital
RECRUITING
Beijing
Peking University First Hospital
RECRUITING
Beijing
The First Hospital of Jilin University
RECRUITING
Changchun
Beijing Chaoyang Hospital
RECRUITING
Chaoyang District
Sichuan Academy of Medical Science Sichuan Provincial People's Hospital
RECRUITING
Chengdu
Sun Yat Sen University Cancer Center
RECRUITING
Guangzhou
The First Affliated Hospital Of Nanchang University
RECRUITING
Nanchang
Peking University Shenzhen Hospital
RECRUITING
Shenzhen
Tianjin Medical University Cancer Institute and Hospital
RECRUITING
Tianjin
Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences
RECRUITING
Tijian
The First Affiliated Hospital of Wenzhou Medical University
RECRUITING
Wenzhou
The Second Affiliated Hospital of Xi'an Jiaotong University
RECRUITING
Xi'an
France
CHU Amiens
RECRUITING
Amiens
CHRU Montpellier - Hopital Saint-Eloi
RECRUITING
Montpellier
CHU Nantes - Hotel Dieu
RECRUITING
Nantes
CHU Bordeaux
RECRUITING
Talence
CHU Toulouse
RECRUITING
Toulouse
CHRU de Tours
RECRUITING
Tours
Germany
Universitaetsklinikum Freiburg
RECRUITING
Freiburg Im Breisgau
Asklepios Klinik Altona
RECRUITING
Hamburg
Universitaetsklinikum Hamburg Eppendorf
RECRUITING
Hamburg
Universitaetsklinik Tuebingen
RECRUITING
Tübingen
Greece
Alexandra General Hospital of Athens
RECRUITING
Athens
Evangelismos S A
RECRUITING
Athens
University General Hospital Attikon General Hospital Of West Attica H Agia Varvara
RECRUITING
Athens
University General Hospital of Ioannina
RECRUITING
Ioannina
India
M S Ramaiah Medical College and Hospital
RECRUITING
Bengaluru
Fortis Memorial Research Institute
RECRUITING
Gurgaon
Bhagwan Mahaveer Cancer Hospital & Research Centre
RECRUITING
Jaipur
Nil Ratan Sircar Medical College and Hospital
RECRUITING
Kolkata
Tata Medical Center
RECRUITING
Kolkata
Rajiv Gandhi Cancer Institute and Research Centre
RECRUITING
New Delhi
Deenanath Mangeshkar Hospital and Research Centre
RECRUITING
Pune
Israel
Samson Assuta Ashdod University Hospital
RECRUITING
Ashdod
Carmel Medical Center
RECRUITING
Haifa
Rambam Med.Center - Hematology Institute
RECRUITING
Haifa
Rabin Medical Center
RECRUITING
Petah Tikva
Sheba Medical Center
RECRUITING
Ramat Gan
Tel Aviv Sourasky Medical Center
RECRUITING
Tel Aviv
Italy
IRCCS Istituto Tumori Giovanni Paolo II
RECRUITING
Bari
A O U Sant Orsola Malpighi
RECRUITING
Bologna
Azienda Sanitaria dell'Alto Adige - Ospedale di Bolzano
RECRUITING
Bolzano
ASST Santi Paolo e Carlo
RECRUITING
Milan
Ospedale San Raffaele di Milano
RECRUITING
Milan
Azienda Ospedaliero Universitaria Maggiore della Carita di Novara
RECRUITING
Novara
Casa di Cura La Maddalena
RECRUITING
Palermo
Ospedale Infermi Rimini
RECRUITING
Rimini
ASST dei Sette Laghi, Ospedale di Circolo e Fonazione Macchi
RECRUITING
Varese
Japan
Chiba Cancer Center
RECRUITING
Chiba
National Hospital Organization Kyushu Medical Center
RECRUITING
Fukuoka
Gunma University Hospital
RECRUITING
Gunma
Shonan Kamakura General Hospital
RECRUITING
Kamakura-shi
University Hospital Kyoto Prefectural University of Medicine
RECRUITING
Kyoto
Matsuyama Red Cross Hospital
RECRUITING
Matsuyama
National Hospital Organization Okayama Medical Center
RECRUITING
Okayama
Sapporo City General Hospital
RECRUITING
Sapporo
The Cancer Institute Hospital of JFCR
RECRUITING
Tokyo
Kanagawa Cancer Center
RECRUITING
Yokohama
Poland
Szpital Uniwersytecki nr 2 im dr Jana Biziela w Bydgoszczy
RECRUITING
Bydgoszcz
Uniwersyteckie Centrum Kliniczne
RECRUITING
Gdansk
Pratia Onkologia Katowice
RECRUITING
Katowice
Centrum Onkologii Ziemi Lubelskiej im sw Jana z Dukli
RECRUITING
Lublin
Specjalistyczny Szpital im dra Alfreda Sokolowskiego w Walbrzychu
RECRUITING
Wałbrzych
MTZ Clinical Research Powered by Pratia
RECRUITING
Warsaw
Republic of Korea
National Cancer Center
RECRUITING
Goyang-si
Seoul National University Bundang Hospital
RECRUITING
Gyeonggi-do
Chonnam National University Hwasun Hospital
RECRUITING
Hwasun
Asan Medical Center
RECRUITING
Seoul
Samsung Medical Center
RECRUITING
Seoul
Seoul National University Hospital
RECRUITING
Seoul
The Catholic University of Korea Seoul St Marys Hospital
RECRUITING
Seoul
Spain
Hosp Univ Vall D Hebron
RECRUITING
Barcelona
Hosp. Clinic de Barcelona
RECRUITING
Barcelona
Hosp. San Pedro de Alcantara
RECRUITING
Cáceres
Hosp Reina Sofia
RECRUITING
Córdoba
Hosp. de Jerez de La Frontera
RECRUITING
Jerez De La Frontera
Hosp. Univ. 12 de Octubre
RECRUITING
Madrid
Clinica Univ. de Navarra
RECRUITING
Pamplona
Hosp Clinico Univ de Salamanca
RECRUITING
Salamanca
Hosp. Univ. Marques de Valdecilla
RECRUITING
Santander
Hosp. Clinico Univ. de Santiago
RECRUITING
Santiago De Compostela
Hosp. Virgen Del Rocio
RECRUITING
Seville
Taiwan
Chang Kung Memorial Hospital
RECRUITING
Kaohsiung City
China Medical University Hospital
RECRUITING
Taichung
Taichung Veterans General Hospital
RECRUITING
Taichung
National Cheng Kung University Hospital
RECRUITING
Tainan
National Taiwan University Hospital
RECRUITING
Taipei
Taipei Veterans General Hospital
RECRUITING
Taipei
Turkey
Ankara Etlik Sehir Hastanesi
RECRUITING
Ankara
Ankara University Medical Faculty
RECRUITING
Ankara
Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital
RECRUITING
Ankara
Liv Hospital Ankara
RECRUITING
Ankara
Memorial Antalya Hospital
RECRUITING
Antalya
Istanbul Florance Nightingale Hospital
RECRUITING
Istanbul
Medipol Mega University Hospital
RECRUITING
Istanbul
Izmir Tinaztepe University Galen Hospital
RECRUITING
Izmir
Mersin University Medical Faculty
RECRUITING
Mersin
Ondokuz Mayis University
RECRUITING
Samsun
Contact Information
Primary
Study Contact
Participate-In-This-Study1@its.jnj.com
844-434-4210
Time Frame
Start Date: 2026-05-31
Estimated Completion Date: 2032-12-08
Participants
Target number of participants: 700
Treatments
Experimental: Arm A: JNJ-79635322
Participants will receive subcutaneous (SC) dose of JNJ-79635322 treatment of a finite duration or intolerable toxicity (whichever is first).
Active_comparator: Arm B: Teclistamab
Participants will receive teclistamab as a SC injection until PD or intolerable toxicity.
Related Therapeutic Areas
Sponsors
Leads: Janssen Research & Development, LLC