Quantified Balance Measures During Stance and Gait: Clinical Relevance for Multiple Sclerosis Patients in Comparison to Patients With Inner Ear Balance Problems. A Longitudinal Clinical Study.

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

The primary objective of this project is to track changes over time in balance control parameters measured during stance and gait for different groups of multiple sclerosis (MS) patients. Our primary goal is to determine whether these changes in balance control over time predict transitions in MS progression to a more disease affected state, and are different from changes over time for patients with balance deficits due to vestibular sensory disorders. A part of this goal is also to determine whether these changes in balance control are correlated with changes in patients' self-reported deficits and are similar to those changes in balance control of patients with peripheral vestibular loss. The secondary objective is to determine for multiple sclerosis (MS) patients the relationship of their balance parameters to different gait speeds, in order to advise them on, and promote via feedback, safe walking speeds. Fulfilling the first of our objectives would lead to better tracking of MS disease changes over time, earlier quantification of onset of symptoms suggesting a worsening of disease status, and, we assume, greater patient satisfaction knowing that quantification of symptoms fits subjective feelings of balance deficits during stance and gait. Achieving the second objective would lead to improved balance during gait. We aim to carry out these objectives using equipment (SwayStar) which we have proven is sensitive to MS induced balance deficits {2}, but costs far less to operate and maintain than previously used quantification tools. We aim to investigate the balance deficits during gait in different MS patient groups using a multimodal approach with a SwayStar system (analysis of balance during stance and gait in terms of trunk-pelvis movements near the centre of mass) and patient questionnaires.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: t
View:

• Balance deficits due to inner ear disease or MS

Locations
Other Locations
Switzerland
Lab for Exp Otoneurology, University Hospital Basel
RECRUITING
Basel
Contact Information
Primary
John Allum, DSc
john.allum@usb.ch
0041-61-2652041
Time Frame
Start Date: 2018-04-01
Estimated Completion Date: 2025-12
Participants
Target number of participants: 300
Treatments
RIS MS patients
Radiologically Isolated Syndrome (RIS) MS patients
CIS MS patients
Clinically Isolated Syndrome (CIS) patients during a stable phase
RRMS patients
Relapsing-remitting (RR) MS patients during a stable phase
SPMS Patients
Secondary progressive MS patients (SPMS)
PPMS Patients
Primary progressive MS patients (PPMS)
Controls
Age and gender matched controls
CI Patients
Cochlear Implant patients pre- and post-operatively
UVL Patients
Unilateral vestibular loss patients in acute and compensated state
Chronic UVL
Chronic unilateral vestibular loss patients
Phobic
Phobic vertigo patients
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Basel, Switzerland

This content was sourced from clinicaltrials.gov