Integrating Genetic and Environmental Risk Scores Into an Algorithm to Predict Multiple Sclerosis Susceptibility
Status: Recruiting
Location: See all (5) locations...
Study Type: Observational
SUMMARY
The purpose of the research study is to identify the genetic, environmental and immune profiles that may increase a person's risk of developing multiple sclerosis (MS). While MS is not a disease caused by a single variation in genetic material (DNA), a single environmental factor, or a single malfunction in immune cells, there are genetic alterations, environmental exposures and immunologic factors that make the development of MS more likely. Obtaining information about who is at risk for MS will be beneficial in the future if the investigators can identify effective ways to prevent or slow down the progression of this disease.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:
• First Degree Relatives of Patients with MS, or
• Patients who have received anti-TNFa therapy as treatment for inflammatory diseases other than MS such as Crohn's disease, psoriasis and rheumatoid arthritis, or
• Patients that have been referred for an evaluation of first presentation of neurologic symptoms but do not have a diagnosis of MS
• Live in the United States
Locations
United States
Massachusetts
Brigham and Women's Hospital
TERMINATED
Boston
Massachusetts General Hospital
TERMINATED
Boston
Maryland
National Institute of Neurological Disorders and Stroke
RECRUITING
Bethesda
New York
Columbia University Irving Center
RECRUITING
New York
Pennsylvania
University of Pittsburgh
RECRUITING
Pittsburgh
Contact Information
Primary
Juliana Oyegunle
jbo2120@cumc.columbia.edu
212-305-2434
Backup
Rifat Iqbal
ri2297@cumc.columbia.edu
212-305-3261
Time Frame
Start Date:2017-10-01
Estimated Completion Date:2040-10
Participants
Target number of participants:5000
Treatments
Received anti-TNFa therapy
Received anti-TNFa therapy
First-degree relative of MS patients
First-degree relative (child, parent or sibling) of a diagnosed MS patient~A subgroup will be asked to undergo magnetic resonance imaging (MRI). Participants may be asked to donate a stool sample for gut flora analysis and a blood sample for ribonucleic acid (RNA) sequencing.