Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis
The purpose of this research is to examine the effects of two different exercise training regimens for managing depression and improving other health indicators among persons with multiple sclerosis (MS). The project will enroll persons with MS and major depressive disorder (MDD) between 18 and 64 years of age. The investigators will enroll a total of 146 participants. This is a Phase-II trial that compares the efficacy of an exercise training program (POWER-MS) compared with a stretching program (FLEX-MS) for immediate and sustained reductions in the severity of depression among persons with MS who have MDD.
• Physical confirmed diagnosis of Multiple Sclerosis (MS)
• Diagnosis of Major Depressive Disorder (MDD) - see below (MINI)
• English as primary language
• Eligible age (between 18 and 64 years old)
• Relapse and steroid free in past 30 days
• Internet and email access
• Willingness to complete the testing and questionnaires, wear the accelerometer, undergo randomization, and engage in exercise testing