Immunoglobulin Deficiency a Treatable Cause of Fatigue in Patients With Multiple Sclerosis (MS)? - A Prospective Observational Fatigue Trial
The investigators hypothesize that hypogammaglobulinemia (defined as IgG serum concentration \<7.0g/L) is a treatable cause of fatigue in people with MS: The primary objective is to prove the link between hypogammaglobulinemia and fatigue in patients with multiple sclerosis. The secondary objective is to show that fatigue is mediated via frequent infections in people with MS and hypogammaglobulinemia.
• Diagnosis of Multiple Sclerosis following McDonald 2017-Criteria
• Age 18-65 years
• Stable MS disease at inclusion (definition: no clinical relapse, no MRI activity, stable disability within the last 12 months)
• Unchanged immunotherapy within the last 12 months
• Expanded Disability Status Scale (EDSS) level \<4 points indicating fully ambulatory patients.
• Capability of written informed consent