Effects of Supervised Progressive Resistance Training on Central Nervous System Functioning (Corticospinal Excitability) and Walking Capacity in Persons With Multiple Sclerosis
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The goal of the present study is to investigate effects of progressive resistance training on central nervous system functioning (corticospinal excitability (CSE)) and walking capacity in persons with multiple sclerosis (pwMS). A total of 54 pwMS will be enrolled and randomized into 1 of 3 groups: high dose resistant training (RT), low dose RT, and waitlist control.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Age ≥ 18 years
• MS diagnosis according to the McDonald diagnostic criteria
• Shows impairments in walking capacity
• Ability to self transport to test and exercise
Locations
Other Locations
Denmark
Department of Public Health
RECRUITING
Aarhus
Department of Nutrition, Exercise and Sports, University of Copenhagen
RECRUITING
Copenhagen
Contact Information
Primary
Lars Hvid, PhD
lhvid@ph.au.dk
93508717
Time Frame
Start Date: 2024-05-01
Estimated Completion Date: 2026-05-31
Participants
Target number of participants: 54
Treatments
Active_comparator: High dose resistance training
10 weeks intervention with 2.5 weekly supervised resistance training sessions (2 or 3 sessions/week for high dose resistance training; 25 sessions in total).
Active_comparator: Low dose resistance training
10 weeks intervention with 1 weekly supervised resistance training session (low dose resistance training; 10 sessions in total).
No_intervention: Waitlist control.
The waitlist control group will initially be instructed to maintain their normal daily activity during the 10 week intervention period. Hereafter, they will be offered a 10 week high dose resistance training intervention that combines supervised and home based exercise sessions .
Related Therapeutic Areas
Sponsors
Collaborators: University of Copenhagen, Aarhus University Hospital
Leads: University of Aarhus