Multiple Sclerosis (MS) Clinical Trials

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Motor Learning of Fall Resistant Skills Through Slip and Trip Exposure in Multiple Sclerosis

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The primary purpose of this interventional study is to examine the overall motor learning capacity from exposure to repeated perturbations among ambulatory people with multiple sclerosis (MS). This project will advance our understanding of learning new motor skills from exposure to external perturbations. If it is proven that people with MS can learn motor skills from perturbation training, the findings from this study will pave a theoretical foundation for applying perturbation training as a promising fall prevention intervention for people with MS.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 45
Maximum Age: 89
Healthy Volunteers: f
View:

• Clinically confirmed multiple sclerosis

• At least 45 years old

• Able to walk independently at least 25 feet

• Able to stand independently for at least 30 seconds

• Patient Determined Disability Steps score between 0 and 4

• Free from pregnancy

• Montreal Cognitive Assessment score of 23 or higher

Locations
United States
Georgia
Georgia State University Biomechanics Lab
RECRUITING
Atlanta
Contact Information
Primary
Feng Yang, Ph.D.
fyang@gsu.edu
404-413-8357
Time Frame
Start Date: 2026-01
Estimated Completion Date: 2028-12
Participants
Target number of participants: 64
Treatments
Experimental: Training Group
During the acquisition session, this group will undergo perturbation training on the treadmill while wearing a safety harness. Then, they will experience an unexpected slip and trip while wearing a safety harness and walking overground. During the 3-month and 6-month retention sessions, they will experience a slip and trip during treadmill walking and a slip and trip during overground walking.
Active_comparator: Control Group
During the acquisition session, this group will walk on the treadmill without perturbations for the same amount of time as the training group. Then, they will experience an unexpected slip and trip while wearing a safety harness and walking overground. During the 3-month and 6-month retention sessions, they will experience a slip and trip during treadmill walking and a slip and trip during overground walking.
Related Therapeutic Areas
Sponsors
Leads: Georgia State University
Collaborators: National Multiple Sclerosis Society

This content was sourced from clinicaltrials.gov