Early Identification of Brain Lesions in Multiple Sclerosis With Phase Sensitive Inversion Recovery MRI: A Cross-sectional Study

Status: Recruiting
Location: See all (3) locations...
Study Type: Observational
SUMMARY

The goal of this observational study is to compare the diagnostic accuracy of Phase-Sensitive Inversion Recovery (PSIR) MRI versus conventional T2-weighted (T2W) and Fluid Attenuated Inversion Recovery (FLAIR) sequences in detecting early brain lesions in patients with Multiple Sclerosis (MS). The study will include male and female participants aged 15-65 years diagnosed with MS per the 2017 McDonald criteria. This study hypothesizes that: * PSIR MRI will detect a significantly higher number of cortical lesions (intracortical, leukocortical, and juxtacortical) compared to conventional T2W and FLAIR sequences in MS patients (p \< 0.05). * Lesions identified exclusively by PSIR will correlate more strongly with clinical measures (EDSS disability scores and SDMT cognitive performance) than those detected by T2W/FLAIR alone, suggesting PSIR's superior sensitivity to clinically relevant pathology.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 15
Maximum Age: 65
Healthy Volunteers: f
View:

• Age between 15-65 years.

• Both sexes.

• Patients with MS according to McDonald Criterion

Locations
Other Locations
Egypt
Banha University Hospitals
RECRUITING
Banhā
El Mounira Multiple Sclerosis Unit
RECRUITING
Cairo
Naser Institute MS Unit
RECRUITING
Cairo
Time Frame
Start Date: 2025-06
Estimated Completion Date: 2025-10
Participants
Target number of participants: 30
Related Therapeutic Areas
Sponsors
Leads: Benha University

This content was sourced from clinicaltrials.gov